POLR2J3 Activators

The assemblage of chemicals classified as POLR2J3 Activators comprises a diverse range of compounds that are primarily involved in the indirect enhancement of the transcriptional activity of RNA polymerase II, to which POLR2J3 belongs. This enhancement is postulated to occur through the modulation of chromatin structure and the transcriptional machinery, thereby facilitating an increase in gene expression. The activators include several histone deacetylase inhibitors like Trichostatin A, Sodium butyrate, Vorinostat, and Phenylbutyrate.

Further, agents such as 5-Azacytidine and Anacardic acid can lead to alterations in the chromatin landscape through effects on DNA methylation and histone acetylation, respectively. S-Adenosylmethionine serves as a universal methyl donor in various biochemical pathways and can influence methylation patterns that affect transcription factor binding and, subsequently, POLR2J3 activity. Additionally, compounds like Beta-estradiol, Caffeic acid phenethyl ester, Epigallocatechin gallate, Retinoic acid, and Genistein can impact various signaling cascades and transcription factors that govern the transcriptional regulation of genes, including those transcribed by RNA polymerase II complexes involving POLR2J3.