POL H Activators
POL H Activators encompass compounds that indirectly modulate the activity of POL H by influencing the cellular pathways and processes related to DNA damage and replication stress. These compounds do not directly interact with POL H but affect the cellular environment and conditions in which POL H operates. A prominent feature of these chemicals is their ability to induce DNA damage or replication stress, thereby activating the cellular DNA damage response mechanisms in which POL H plays a crucial role. For example, compounds like cisplatin, camptothecin, and mitomycin C induce various forms of DNA lesions, which necessitate the activation of TLS pathways involving POL H to bypass these lesions during DNA replication.
Another characteristic of these activators is their diverse nature and modes of action. While some, like hydroxyurea and aphidicolin, induce replication stress, others, such as ethidium bromide and benzopyrene, cause structural DNA alterations. These different types of DNA damage and stress conditions call for the enhanced activity of specialized DNA polymerases like POL H, which are adept at dealing with such challenges during DNA replication. In conclusion, the chemical class of "POL H Activators" includes a range of compounds that create cellular conditions necessitating the increased activity of POL H. By inducing DNA damage and replication stress, these compounds indirectly enhance the role of POL H in maintaining genomic integrity during DNA replication. Their diverse mechanisms of action reflect the complexity of the cellular response to DNA damage and the critical role of POL H in this process.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin induces DNA damage, which can upregulate the TLS pathway and consequently enhance the activity of POL H as it plays a crucial role in bypassing platinum-induced DNA lesions. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin induces DNA strand breaks by inhibiting topoisomerase I. The resulting DNA damage can enhance POL H activity as it is involved in the bypass of these lesions during DNA replication. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, leading to dNTP pool imbalances and stalling of replication forks, which can indirectly enhance POL H activity as it aids in bypassing stalled replication forks. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aphidicolin is a DNA polymerase inhibitor that can induce replication stress. This stress might upregulate POL H activity to help bypass the blocks caused by aphidicolin. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $56.00 $133.00 | 2 | |
MMS is an alkylating agent that induces DNA damage. This damage can lead to an upregulation of POL H as it is involved in bypassing alkylated DNA during replication. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C induces DNA cross-links. The resultant DNA damage can enhance POL H activity as part of the cellular DNA damage tolerance mechanism. | ||||||
Ethidium bromide | 1239-45-8 | sc-203735 sc-203735A sc-203735B sc-203735C | 1 g 5 g 25 g 100 g | $48.00 $150.00 $588.00 $2086.00 | 12 | |
Ethidium bromide intercalates into DNA, causing structural distortions. These distortions can upregulate POL H activity as part of the cellular mechanism to bypass such lesions during DNA replication. | ||||||
Acrylamide Solution, 40% | 79-06-1 | sc-3721 | 1 L | $100.00 | ||
Acrylamide forms adducts with DNA, leading to DNA damage. This damage might enhance POL H activity as it plays a role in bypassing acrylamide-induced DNA lesions. | ||||||
Benzo[a]pyrene | 50-32-8 | sc-257130 | 1 g | $612.00 | 4 | |
Benzopyrene, a polycyclic aromatic hydrocarbon, forms DNA adducts. The resultant DNA damage can potentially enhance POL H activity in the process of bypassing these lesions. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic trioxide can induce oxidative stress and DNA damage. This stress and damage might lead to an upregulation of POL H activity as part of the DNA damage tolerance response. | ||||||