POEM Inhibitors
Chemical inhibitors of POEM can exert their inhibitory effects through various mechanisms by targeting specific signaling pathways and cellular processes. LY294002 and Wortmannin are both phosphoinositide 3-kinase (PI3K) inhibitors that can lead to the functional inhibition of POEM by disrupting the PI3K/AKT pathway, which is integral to cell survival and proliferation. This disruption can result in altered cellular adhesion and migration, processes in which POEM is involved. Similarly, Dasatinib and PP2, as Src family kinase inhibitors, can inhibit the role of POEM in cell adhesion and migration by interfering with the signaling cascades that regulate cytoskeletal structure and cell-to-cell interactions. Marimastat and GM6001, both matrix metalloproteinase (MMP) inhibitors, can hinder the degradation of the extracellular matrix, a process necessary for cell migration, thus indirectly inhibiting the functional role of POEM in promoting cellular movement.
In a parallel manner, the function of POEM can be indirectly inhibited by chemicals interfering with the MAPK pathway. PD98059 and U0126 selectively inhibit the mitogen-activated protein kinase kinase (MEK), which is part of the MAPK/ERK pathway. Inhibition of this pathway can lead to a decrease in POEM's role in signal transduction related to cell proliferation and differentiation. SP600125, as an inhibitor of c-Jun N-terminal kinase (JNK), can modulate cell signaling related to inflammation and apoptosis, which are processes where POEM's function can be involved. SB203580's specific inhibition of p38 MAP kinase also serves to impede the inflammatory responses and apoptotic processes where POEM is implicated. Furthermore, Rapamycin, by targeting the mTOR pathway, can indirectly inhibit POEM by affecting cell growth and proliferation. Lastly, Y-27632 inhibits the Rho/ROCK pathway, which can lead to reduced cell motility and contraction, further illustrating the range of pathways through which POEM's function can be inhibited.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor. Since PI3K signaling is crucial for many cellular processes, including cell survival and proliferation, inhibition by LY294002 can disrupt downstream effects, potentially inhibiting POEM's role in cellular adhesion and migration. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Marimastat is a broad-spectrum matrix metalloproteinase (MMP) inhibitor. As MMPs are involved in the degradation of extracellular matrix, which is critical for cellular migration, its inhibition can impede the migration process where POEM is a contributing factor. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
GM6001, another MMP inhibitor, functions similarly to Marimastat by preventing the breakdown of extracellular matrix, which is necessary for cell movement, indirectly inhibiting the functional role of POEM in cell migration. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a Src family kinase inhibitor. Src kinases play roles in multiple signaling pathways that regulate cytoskeletal structure, adhesion, and migration, where POEM is implicated, thus Dasatinib can inhibit POEM's associated functions. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is involved in cell signaling related to inflammation and apoptosis. By inhibiting JNK, SP600125 can indirectly inhibit POEM's function in these cellular processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is part of the MAPK/ERK pathway. Inhibition of this pathway can indirectly inhibit POEM's role in signal transduction related to cell proliferation and differentiation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent PI3K inhibitor like LY294002 and can similarly inhibit POEM by disrupting the PI3K/AKT pathway, leading to altered cell survival, proliferation, and migration where POEM is involved. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 specifically inhibits p38 MAP kinase, which is involved in inflammatory responses and apoptosis. Inhibiting p38 MAP kinase can indirectly inhibit POEM's function in these cellular responses. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, similar to PD98059, and can inhibit POEM by disrupting the ERK pathway, which is involved in regulating cell cycle progression and differentiation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mammalian target of rapamycin (mTOR) pathway, which is important in cell growth and proliferation. Inhibiting mTOR can indirectly inhibit POEM by affecting these cellular processes. | ||||||