PMFBP1 Inhibitors
Spermidine and Spermine, are central to the polyamine signaling pathway, and synthetic molecules such as DFMO, which disrupts polyamine biosynthesis. By modulating polyamine levels, these substances may indirectly affect PMFBP1 activity. Protein synthesis is another target of indirect inhibitors. Cycloheximide and puromycin, for example, can reduce PMFBP1 levels or those of its interacting proteins by halting protein synthesis. On the other hand, compounds like MG132 hinder proteasomal degradation, which could lead to the accumulation of proteins that interact with PMFBP1, potentially modifying its function.
Autophagy, a cellular housekeeping process, can also be modulated to affect PMFBP1. Chloroquine and bafilomycin A1 disrupt lysosomal function, which could influence PMFBP1 turnover or the degradation of its regulatory proteins. Rapamycin, by inducing autophagy, may similarly affect PMFBP1's stability or interactions. Furthermore, cellular signaling pathways are important targets for indirect inhibition. LY294002, a PI3K inhibitor, alters various cellular processes that might impact the cellular context of PMFBP1. Rapamycin's inhibition of the mTOR pathway is another example of indirect modulation, potentially affecting PMFBP1 through changes in autophagy and other cellular responses.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
As a polyamine, it can alter the polyamine signaling pathway, which in turn may modulate PMFBP1's interaction with its targets. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Similar to spermidine, spermine is a biogenic polyamine that can affect polyamine homeostasis and potentially influence PMFBP1 functions. | ||||||
Difluoromethylornithine | 70052-12-9 | sc-204723 sc-204723A sc-204723B sc-204723C sc-204723D sc-204723E | 10 mg 25 mg 100 mg 250 mg 1 g 5 g | $58.00 $130.00 $158.00 $311.00 $964.00 $4726.00 | 2 | |
Inhibits ornithine decarboxylase, potentially altering polyamine synthesis and thereby affecting the polyamine-mediated regulation of PMFBP1. | ||||||
Methylglyoxal solution | 78-98-8 | sc-250394 sc-250394A sc-250394B sc-250394C sc-250394D | 25 ml 100 ml 250 ml 500 ml 1 L | $143.00 $428.00 $469.00 $739.00 $1418.00 | 3 | |
A glycolysis by-product that can modify protein function through glycation, which may affect PMFBP1's binding capacity. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits protein synthesis which can alter the level of PMFBP1's interacting partners, thereby indirectly affecting its function. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Known to interfere with lysosomal function and autophagy, potentially impacting PMFBP1 by altering its degradation or the degradation of associated regulatory proteins. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $40.00 $210.00 $816.00 $65.00 | 394 | |
Induces premature chain termination during protein synthesis, potentially decreasing the levels of PMFBP1 or its associated proteins. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Inhibitor of the V-ATPase proton pump, affecting lysosomal acidification and autophagy, can indirectly affect PMFBP1 stability or interaction with binding partners. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor that can lead to the accumulation of polyubiquitinated proteins, possibly affecting PMFBP1's function or interaction with other proteins. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
Acts as an inhibitor of autophagy through its effect on PI3K, may influence PMFBP1's level of expression or its interaction with autophagy-related proteins. | ||||||