PMCA2 Activators
PMCA2 activators constitute a diverse group of chemicals that modulate the activity of the Plasma Membrane Calcium ATPase isoform 2, primarily through indirect mechanisms related to calcium homeostasis and signaling pathways. Thapsigargin and Cyclopiazonic acid indirectly activate PMCA2 by inhibiting SERCA, leading to cytosolic calcium elevation and compensatory PMCA2 activation. Ruthenium Red, a non-specific inhibitor of Ca2+ transporters, disrupts calcium flux, triggering PMCA2 activation to restore calcium homeostasis. Caloxin 1B1, a PMCA-specific inhibitor, induces intracellular calcium elevation, prompting compensatory PMCA2 activation upon its inhibition. Vanadate modulates tyrosine phosphorylation, indirectly influencing PMCA2 activity. Carboxyeosin alters calcium dynamics, prompting compensatory PMCA2 activation to regulate calcium homeostasis. CGP-37157 affects mitochondrial calcium handling, influencing PMCA2 activation.
SKF 96365, an inhibitor of receptor-operated calcium channels, perturbs calcium influx, triggering compensatory PMCA2 activation. NS309, an activator of calcium-activated channels, influences calcium dynamics, prompting compensatory PMCA2 activation. TMB-8 inhibits intracellular calcium release, indirectly activating PMCA2 to maintain calcium homeostasis. CGS 9343B, a T-type calcium channel blocker, modulates calcium influx, triggering compensatory PMCA2 activation. KB-R7943, an inhibitor of the reverse mode of Na+/Ca2+ exchanger, alters sodium/calcium exchange, indirectly activating PMCA2 to regulate calcium homeostasis. Collectively, these chemicals provide valuable insights into the intricate regulatory network governing PMCA2 activity and its role in maintaining calcium homeostasis. Understanding the interplay between these chemicals and the regulatory mechanisms involving PMCA2 offers a comprehensive view of the molecular processes governing calcium signaling and cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin, a SERCA inhibitor, indirectly activates PMCA2 by disrupting calcium homeostasis. Inhibition of SERCA leads to cytosolic calcium elevation, triggering compensatory PMCA2 activation to maintain calcium balance. This indirect activation underscores the interplay between SERCA and PMCA2 in calcium regulation. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic acid, a specific SERCA inhibitor, indirectly activates PMCA2 by disrupting calcium homeostasis. Inhibition of SERCA by cyclopiazonic acid leads to cytosolic calcium elevation, prompting compensatory PMCA2 activation to restore calcium balance. This indirect activation highlights the regulatory connection between SERCA and PMCA2 in calcium signaling. | ||||||
NS309 | 18711-16-5 | sc-253202 | 5 mg | $110.00 | ||
NS309, an activator of small-conductance Ca2+-activated K+ channels, indirectly activates PMCA2 by modulating calcium-activated channels. Activation of small-conductance Ca2+-activated K+ channels by NS309 influences calcium dynamics, triggering compensatory PMCA2 activation to regulate calcium homeostasis. This indirect activation underscores the interplay between calcium-activated channels and PMCA2 activity. | ||||||
TMB-8 • HCl | 53464-72-5 | sc-3522 sc-3522A | 10 mg 50 mg | $43.00 $129.00 | 10 | |
TMB-8, an intracellular calcium release inhibitor, indirectly activates PMCA2 by influencing calcium release. Inhibition of intracellular calcium release by TMB-8 alters calcium dynamics, prompting compensatory PMCA2 activation to maintain calcium homeostasis. This indirect activation highlights the regulatory role of intracellular calcium release in modulating PMCA2 activity. | ||||||
CGS 9343B | 109826-27-9 | sc-203883 | 10 mg | $320.00 | ||
CGS 9343B, a T-type calcium channel blocker, indirectly activates PMCA2 by modulating T-type calcium channels. Inhibition of T-type calcium channels by CGS 9343B affects calcium influx, triggering compensatory PMCA2 activation to restore calcium homeostasis. This indirect activation emphasizes the regulatory interplay between T-type calcium channels and PMCA2 activity. | ||||||