PMCA2 Inhibitors
PMCA2 inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of the Plasma Membrane Calcium ATPase 2 (PMCA2) pump. PMCA2 is one of the isoforms of the PMCA family, which are calcium pumps responsible for maintaining calcium homeostasis by extruding calcium ions (Ca²⁺) from the cytosol to the extracellular space. PMCA2 is highly expressed in tissues that require precise calcium regulation, such as the brain, inner ear, and certain secretory cells. By inhibiting PMCA2, researchers can modulate calcium efflux in these cells, disrupting the tightly controlled balance of intracellular calcium concentrations. This allows scientists to study how altered calcium handling affects cellular processes such as signal transduction, membrane dynamics, and calcium-dependent enzymatic activity.
The molecular mechanisms of PMCA2 inhibitors typically involve binding to specific sites on the pump, such as the catalytic domain or regulatory regions, that are essential for its ATP-dependent calcium transport function. These inhibitors may work by preventing ATP hydrolysis, which is required for the conformational changes that drive calcium ion extrusion, or by blocking the binding of calcium ions to the pump's active site. By interfering with PMCA2 function, inhibitors provide valuable tools for exploring the intricate role of calcium signaling in cellular physiology. In particular, PMCA2 inhibitors help researchers investigate the significance of calcium regulation in processes like neuronal activity, synaptic plasticity, and calcium-dependent signaling pathways. Through the inhibition of PMCA2, scientists can gain insights into how disruptions in calcium homeostasis influence cellular function and contribute to broader physiological mechanisms involving calcium-dependent processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red, while not a specific PMCA2 inhibitor, is included for its potential impact on calcium homeostasis. It acts as a general inhibitor of various calcium pumps and channels. Its interference with calcium transport systems can indirectly influence PMCA2 activity by altering cellular calcium levels. | ||||||
CGP 37157 | 75450-34-9 | sc-202097 sc-202097A | 5 mg 25 mg | $115.00 $463.00 | 3 | |
CGP-37157 is a mitochondrial Na+/Ca2+ exchange inhibitor that can indirectly affect PMCA2 function. By influencing mitochondrial calcium handling, CGP-37157 may impact the overall cellular calcium balance, potentially leading to alterations in PMCA2-mediated calcium extrusion. | ||||||
KB-R7943 MESYLATE | 182004-65-5 | sc-202681 | 10 mg | $160.00 | 4 | |
KB-R7943 is a sodium/calcium exchanger (NCX) inhibitor that indirectly modulates PMCA2 function. By affecting the balance between sodium and calcium fluxes, KB-R7943 can influence cytosolic calcium levels, potentially impacting PMCA2-mediated calcium extrusion. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium Orthovanadate, a protein tyrosine phosphatase (PTP) inhibitor, is included for its potential role in modulating PMCA2. PTPs can influence signaling pathways that may, in turn, affect PMCA2 activity. The indirect impact of Sodium Orthovanadate on PMCA2 suggests a potential regulatory link through tyrosine phosphorylation events. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil, a calcium channel blocker, is included for its indirect influence on PMCA2 function. By reducing calcium entry through voltage-gated channels, Verapamil can affect the overall cellular calcium load, potentially influencing PMCA2-mediated calcium extrusion. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 is a transient receptor potential (TRP) channel inhibitor that indirectly impacts PMCA2 function. By modulating calcium entry through TRP channels, SKF-96365 can alter the cellular calcium concentration, potentially influencing the demand for PMCA2-mediated calcium extrusion. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB is an inositol trisphosphate receptor (IP3R) inhibitor, indirectly affecting PMCA2. By modulating IP3R-mediated calcium release from intracellular stores, 2-APB can influence the overall cellular calcium dynamics, potentially impacting the need for PMCA2-mediated calcium extrusion. | ||||||