PLC β1 Inhibitors
PLC β1 inhibitors belong to a class of chemical compounds specifically designed to target and inhibit the activity of phospholipase C beta 1 (PLC β1), an essential enzyme in cellular signal transduction pathways. These inhibitors are valuable tools in the field of molecular biology and pharmacology for their ability to modulate intracellular signaling cascades. PLC β1 is a member of the phospholipase C (PLC) family of enzymes, which play a pivotal role in the regulation of various cellular processes by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into two secondary messengers, inositol trisphosphate (IP3) and diacylglycerol (DAG). These secondary messengers, in turn, trigger a cascade of intracellular events, including the release of calcium ions from intracellular stores and the activation of protein kinase C (PKC). PLC β1 is particularly abundant in neuronal tissues, where it participates in neurotransmitter signaling, and in various immune cells, where it contributes to immune response modulation.
PLC β1 inhibitors are designed to interfere with the enzymatic activity of PLC β1, thereby disrupting downstream signaling pathways. They typically target the catalytic domain of PLC β1, preventing it from cleaving PIP2 and, consequently, reducing the production of IP3 and DAG. Researchers use these inhibitors in laboratory settings to elucidate the role of PLC β1 in various cellular processes, studying the consequences of its inhibition on intracellular calcium levels, PKC activation, and downstream gene expression. By understanding the intricate mechanisms regulated by PLC β1, scientists gain insights into the underlying molecular events that govern cell physiology and pathophysiology, paving the way for future applications in drug development and disease management.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisoprolol | 66722-44-9 | sc-278792 | 25 mg | $204.00 | ||
Bisoprolol is a selective β1-adrenergic receptor blocker. It competitively inhibits the binding of catecholamines to β1 receptors, reducing heart rate and contractility. | ||||||
1-[4-(2-methoxyethyl)phenoxy]-3-propan-2-ylamino-propan-2-ol | 51384-51-1 | sc-264643 | 2.5 g | $102.00 | ||
Metoprolol is a selective β1-adrenergic receptor antagonist. It blocks the effects of catecholamines on β1 receptors in the heart, reducing heart rate and blood pressure, making it effective for various cardiovascular conditions. | ||||||
(RS)-Atenolol | 29122-68-7 | sc-204895 sc-204895A | 1 g 10 g | $77.00 $408.00 | 1 | |
Atenolol selectively blocks β1-adrenergic receptors in the heart, reducing heart rate and myocardial contractility. This mechanism is utilized for hypertension, angina, and arrhythmias. | ||||||
Carvedilol | 72956-09-3 | sc-200157 sc-200157A sc-200157B sc-200157C sc-200157D | 100 mg 1 g 10 g 25 g 100 g | $122.00 $235.00 $520.00 $979.00 $1500.00 | 2 | |
Carvedilol is a non-selective β-blocker with additional α1-adrenergic receptor blocking properties. It reduces cardiac workload by decreasing heart rate and contractility, used for heart failure and hypertension. | ||||||
Nebivolol | 99200-09-6 | sc-279910 | 100 mg | $803.00 | 1 | |
Nebivolol is a β1-adrenergic receptor antagonist with vasodilatory properties. It decreases heart rate and blood pressure by blocking β1 receptors, aiding in hypertension and heart failure. | ||||||
Esmolol | 81147-92-4 | sc-279019B sc-279019A sc-279019 | 50 mg 100 mg 500 mg | $100.00 $150.00 $650.00 | 1 | |
Esmolol is a short-acting, selective β1-adrenergic receptor antagonist. It rapidly decreases heart rate and contractility, making it useful for controlling heart rate in acute situations such as arrhythmias. | ||||||
Arotinolol | 68377-92-4 | sc-481597 | 100 mg | $380.00 | ||
Arotinolol is a β1-adrenergic receptor antagonist with α1-blocking properties. By blocking β1 receptors, it reduces heart rate and contractility, and its α1 blockade can help lower blood pressure. | ||||||
rac Bopindolol | 62658-63-3 | sc-503926 | 5 mg | $380.00 | ||
Bopindolol is a non-selective β-adrenergic receptor antagonist. It inhibits both β1 and β2 receptors, reducing heart rate and myocardial contractility, useful in various cardiovascular disorders. | ||||||
rac Practolol | 6673-35-4 | sc-476329 | 100 mg | $380.00 | ||
Practolol is a non-selective β-blocker. It competitively inhibits β1 and β2 receptors, reducing heart rate and contractility, and is primarily used to manage conditions like hypertension and angina. | ||||||
Pindolol | 13523-86-9 | sc-204847 sc-204847A | 100 mg 1 g | $194.00 $760.00 | ||
Pindolol is a non-selective β-adrenergic receptor antagonist with partial agonist activity. It competitively blocks β1 and β2 receptors, reducing heart rate and contractility while having some intrinsic activity. | ||||||