PKD Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $343.00 $1642.00 | 20 | |
Calphostin C is a potent inhibitor of protein kinase C (PKC), characterized by its ability to selectively bind to the regulatory domain of the enzyme. This interaction disrupts the phosphorylation cascade, altering signal transduction pathways. Its unique structure allows for specific conformational changes in PKC, influencing enzyme activity and substrate recognition. The compound's kinetic profile reveals a competitive inhibition mechanism, providing insights into the modulation of cellular signaling dynamics. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol acts as a potent modulator of protein kinase D (PKD) through its ability to interact with specific phosphorylation sites, influencing the enzyme's activity. Its unique polyphenolic structure facilitates hydrogen bonding and hydrophobic interactions, enhancing selectivity for PKD. This compound exhibits a distinct kinetic behavior, demonstrating non-competitive inhibition, which alters the enzyme's conformational dynamics and impacts downstream signaling pathways. | ||||||
CID 755673 | 521937-07-5 | sc-205246 | 10 mg | $203.00 | 1 | |
CID 755673 functions as a selective inhibitor of protein kinase D (PKD) by engaging in specific molecular interactions that stabilize its inactive conformation. Its unique structural features allow for effective binding at the enzyme's active site, disrupting substrate access. The compound exhibits a rapid association and slower dissociation rate, leading to prolonged inhibition. Additionally, its ability to form stable complexes with PKD enhances its specificity, influencing cellular signaling cascades. | ||||||
TGF-β RI Kinase Inhibitor V | 627536-09-8 | sc-203294 | 2 mg | $88.00 | 3 | |
TGF-β RI Kinase Inhibitor V acts as a potent modulator of protein kinase D (PKD) through its unique ability to disrupt the phosphorylation cascade. By selectively targeting the ATP-binding pocket, it alters the enzyme's conformational dynamics, preventing substrate phosphorylation. The compound's distinct binding affinity results in a notable alteration of downstream signaling pathways, showcasing its role in fine-tuning cellular responses. Its kinetic profile reveals a fast onset of action, contributing to sustained inhibition. | ||||||
Gossypol | 303-45-7 | sc-200501 sc-200501A | 25 mg 100 mg | $116.00 $230.00 | 12 | |
Gossypol exhibits intriguing interactions with protein kinase D (PKD) by acting as a competitive inhibitor, effectively blocking substrate access to the active site. Its unique structural features allow for specific hydrogen bonding and hydrophobic interactions, enhancing binding affinity. This compound influences the allosteric regulation of PKD, leading to altered enzymatic activity and modulation of cellular signaling networks. The reaction kinetics indicate a gradual onset, suggesting prolonged effects on PKD activity. | ||||||