Pim-3 Inhibitors
Items 1 to 10 of 13 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rottlerin | 82-08-6 | sc-3550 sc-3550B sc-3550A sc-3550C sc-3550D sc-3550E | 10 mg 25 mg 50 mg 1 g 5 g 20 g | $84.00 $166.00 $302.00 $2091.00 $5212.00 $16657.00 | 51 | |
Rottlerin functions as a Pim-3 inhibitor, characterized by its selective binding to the kinase domain through unique hydrogen bonding and hydrophobic interactions. This compound exhibits a distinct conformational flexibility, allowing it to adapt to various target sites, which can modulate enzyme activity. Its lipophilic properties enhance membrane permeability, influencing cellular uptake and localization, while its kinetic profile suggests a potential for prolonged interaction with target proteins, affecting downstream signaling pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid that can inhibit various protein kinases and might reduce Pim-3 activity through non-specific kinase inhibition. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $92.00 $245.00 | 17 | |
Ro 31-8220 acts as a selective inhibitor of Pim-3, showcasing a unique ability to disrupt ATP binding through specific electrostatic interactions within the kinase domain. Its structural rigidity contributes to a stable binding conformation, which can effectively block substrate access. The compound's hydrophobic regions facilitate interactions with lipid membranes, potentially altering membrane dynamics and influencing protein localization. Additionally, its kinetic behavior indicates a rapid onset of action, impacting cellular signaling cascades. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent, non-selective inhibitor of protein kinases that could inhibit Pim-3 kinase activity. | ||||||
TCS PIM-1 4a | 438190-29-5 | sc-296450 sc-296450A | 10 mg 50 mg | $64.00 $346.00 | ||
A small molecule inhibitor known to target Pim-1 kinase, which may also inhibit Pim-3 due to structural similarities. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor that could decrease Pim-3 expression indirectly by affecting the PI3K/AKT pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor that may downregulate Pim-3 expression as part of its broad regulatory effects on cell growth and proliferation. | ||||||
AZD1208 | 1204144-28-4 | sc-503188 | 10 mg | $322.00 | 1 | |
Pim kinase inhibitor that could directly inhibit Pim-3 activity. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $153.00 $938.00 | 5 | |
Multitargeted tyrosine kinase inhibitor that might inhibit Pim-3 kinase activity. | ||||||
Silvestrol | 697235-38-4 | sc-507504 | 1 mg | $920.00 | ||
Translation inhibitor that could decrease Pim-3 protein levels by inhibiting eukaryotic translation initiation. | ||||||