PI 3-kinase p85α Inhibitors
Common PI 3-kinase p85α Inhibitors include, but are not limited to Wortmannin CAS 19545-26-7, LY 294002 CAS 154447-36-6, GDC-0941 CAS 957054-30-7, Quercetin CAS 117-39-5 and Autophagy Inhibitor, 3-MA CAS 5142-23-4.
PI 3-kinase p85α inhibitors are a specialized class of chemical agents designed for research purposes, focusing on the modulation of the phosphoinositide 3-kinase (PI3K) pathway, particularly through targeting the p85α regulatory subunit of PI3K. These inhibitors are crucial in the study of cellular processes and signal transduction pathways in various biochemical and molecular biology research fields. The p85α subunit plays a significant role in the PI3K enzyme family, involved in a range of cellular functions such as growth, proliferation, differentiation, motility, survival, and intracellular trafficking. Class I PI3Ks, the most studied group, are heterodimeric molecules composed of a regulatory (p85) and a catalytic (p110) subunit, with p85α stabilizing and regulating p110. It also aids in recruiting PI3K to the cell membrane upon activation by receptors like receptor tyrosine kinases (RTKs), leading to the phosphorylation of phosphatidylinositol (4,5)-bisphosphate (PIP2) into phosphatidylinositol (3,4,5)-trisphosphate (PIP3), a key second messenger.
The mechanism of action of PI 3-kinase p85α inhibitors varies, including direct inhibition, where the inhibitor binds to the p85α subunit, altering its conformation and interaction with the p110 subunit, thus reducing PI3K activation and PIP3 production. Indirect inhibition involves interference with the interaction between p85α and other signaling molecules or receptors, preventing PI3K complex activation at the cell membrane. Some inhibitors function allosterically, binding to sites other than the active site on p85α, inducing conformational changes that diminish enzyme activity. These inhibitors are invaluable in research for dissecting the PI3K signaling pathway, allowing the study of signal transduction and the effects of PI3K inhibition on cell behavior. They are also instrumental in investigating the role of PI3K signaling in disease mechanisms and probing the interactions between PI3K and other cellular proteins or pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a covalent inhibitor of PI3Ks. While it primarily inhibits the catalytic activity, prolonged exposure might lead to down-regulation of PI3K p85α through feedback loops. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a morpholine chemical that acts as a potent PI3K inhibitor. Its inhibitory effects could potentially lead to reduced expression or stability of PI3K p85α over time. | ||||||
GDC-0941 | 957054-30-7 | sc-364498 sc-364498A | 5 mg 10 mg | $184.00 $195.00 | 2 | |
GDC-0941 is a selective class I PI3K inhibitor. By inhibiting the PI3K pathway, it might indirectly affect the stability and expression of PI3K p85α. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid found in many foods, has been shown to inhibit PI3Ks. It might also down-regulate PI3K p85α through its broad range of biological activities. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
This compound primarily inhibits class III PI3K but might have off-target effects on class I PI3Ks, potentially impacting PI3K p85α expression. | ||||||
PI-103 | 371935-74-9 | sc-203193 sc-203193A | 1 mg 5 mg | $32.00 $128.00 | 3 | |
PI-103 is a potent PI3K and mTOR inhibitor. It could impact the stability and expression of PI3K p85α by inhibiting the pathway. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $207.00 | 8 | |
BEZ235 is a dual PI3K/mTOR inhibitor. By inhibiting both targets, it might indirectly down-regulate PI3K p85α. | ||||||
BKM120 | 944396-07-0 | sc-364437 sc-364437A sc-364437B sc-364437C | 5 mg 10 mg 25 mg 50 mg | $173.00 $230.00 $275.00 $332.00 | 9 | |
BKM120 is a pan-PI3K inhibitor and might impact the expression or stability of PI3K p85α in cells. | ||||||
IC-87114 | 371242-69-2 | sc-364509 sc-364509A | 5 mg 50 mg | $140.00 $1060.00 | 1 | |
IC87114 is a selective PI3Kδ inhibitor. Although selective, it might have indirect effects on PI3K p85α expression in certain contexts. | ||||||
PI 3-Kβ Inhibitor VI, TGX-221 | 663619-89-4 | sc-203190 | 1 mg | $437.00 | ||
TGX-221 is a highly selective PI3Kβ inhibitor. While specific for PI3Kβ, it could have indirect effects on PI3K p85α in complex cellular environments. | ||||||