PHR1 inhibitors, belonging to the broader class of chemical compounds known as protein kinase inhibitors, are a group of molecules specifically designed to target and modulate the activity of the PHR1 protein. PHR1, which stands for Photoreceptor 1, is a type of protein kinase that plays a critical role in various cellular processes, particularly those related to signal transduction and gene expression. These inhibitors are synthetic or naturally occurring compounds that interact with the PHR1 protein, either by binding to its active site or by disrupting its function indirectly, ultimately resulting in the regulation of downstream signaling pathways.
The precise mechanism of PHR1 inhibitors may vary depending on the specific compound, but their primary goal is to interfere with the catalytic activity of PHR1. This inhibition can occur through various mechanisms, such as competitive binding to the enzyme's active site, allosteric modulation, or interfering with the protein's phosphorylation and dephosphorylation cycle. By regulating PHR1 activity, these inhibitors have the to impact a wide range of cellular processes, including cell growth, differentiation, and responses to external stimuli like light in the case of photoreceptors. This class of compounds holds promise for researchers and developers as they seek to elucidate the precise roles of PHR1 in cellular signaling.
Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Inhibits RNA polymerase II transcription, suppressing PHR1 expression, and inducing apoptosis in cancer cells. | ||||||
THZ1 | 1604810-83-4 | sc-507542 | 1 mg | $95.00 | ||
Selective CDK7 inhibitor that disrupts transcription initiation by targeting the CDK7/cyclin H complex, downregulating PHR1-related genes. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
Bromodomain inhibitor that competitively binds to BRD4, disrupting PHR1 transcription by preventing BRD4-mediated chromatin remodeling. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Blocks RNA synthesis by binding to DNA, indirectly inhibiting PHR1 expression by disrupting transcription. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
CDK inhibitor that suppresses PHR1 expression by targeting CDK9 and CDK7, preventing RNA polymerase II-mediated transcription. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
Selective p300/CBP inhibitor, reducing PHR1 acetylation, and inhibiting its transcriptional activity by disrupting histone acetylation. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
Inhibits CDK9, preventing phosphorylation of RNA polymerase II C-terminal domain and suppressing PHR1 transcription. | ||||||
Actinomycin V | 18865-48-0 | sc-507379 | 1 mg | $450.00 | ||
Interferes with RNA synthesis by binding to DNA, leading to the inhibition of PHR1 expression by blocking transcription. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $242.00 $871.00 | 1 | |
Potent CDK inhibitor that targets CDK1, CDK2, CDK5, and CDK9, suppressing PHR1 transcription by inhibiting CDK-dependent phosphorylation. | ||||||
SGC-CBP30 | 1613695-14-9 | sc-473871 sc-473871A | 5 mg 10 mg | $178.00 $338.00 | ||
CBP/P300 bromodomain inhibitor that reduces PHR1 acetylation and interferes with its transcriptional activity. |