Pho85 Inhibitors
Pho85 inhibitors primarily target the realm of cyclin-dependent kinases (CDKs), enzymes critical for various stages of the cell cycle, especially in yeasts like Saccharomyces cerevisiae. Given the intrinsic similarity in the kinase domain structures of these CDKs, a plethora of chemicals known to target CDKs can exert an inhibitory effect on Pho85, albeit indirectly. Key representatives of this class include Roscovitine, Purvalanol A, and Flavopiridol. These molecules, recognized for their potent CDK inhibitory activity, can suppress the function of Pho85, thereby intervening in the associated signaling pathways.
Moreover, the interaction of these chemicals with multiple CDKs implies a broad-spectrum mechanism of action, which, while advantageous in certain scenarios, warrants careful considerations in others due to potential off-target effects. Milciclib and Palbociclib (PD 0332991), while primarily targeting mammalian CDKs, exhibit an indirect influence on Pho85 due to their overarching inhibitory spectrum. Additionally, compounds like Indirubin-3'-monoxime and Butyrolactone I showcase the diversity of structures and functionalities within this chemical class.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Cyclin-dependent kinase inhibitor that can inhibit various CDKs, potentially affecting Pho85. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Another CDK inhibitor that, by virtue of inhibiting related kinases, can indirectly influence Pho85's activity. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Targets multiple CDKs and thus can indirectly affect Pho85. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $242.00 $871.00 | 1 | |
Known to inhibit CDKs and can thus potentially suppress Pho85's kinase activity. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
While mainly targeting mammalian CDKs, its broad CDK inhibitory properties can indirectly affect Pho85. | ||||||
SU 9516 | 377090-84-1 | sc-222330 sc-222330A | 5 mg 25 mg | $122.00 $383.00 | 3 | |
CDK inhibitor that, by affecting related kinases, can influence Pho85. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $77.00 $315.00 $658.00 | 1 | |
A known CDK inhibitor which can affect a variety of CDKs, including potentially Pho85. | ||||||
Butyrolactone I | 87414-49-1 | sc-201533 sc-201533A | 200 µg 1 mg | $120.00 $504.00 | 1 | |
Inhibits CDKs, thereby can play a role in potentially modifying the action of Pho85. | ||||||
PHA-848125 | 802539-81-7 | sc-364581 sc-364581A | 5 mg 10 mg | $304.00 $555.00 | ||
While it primarily targets mammalian CDKs, its activity against CDKs can influence Pho85. | ||||||
Fascaplysin | 114719-57-2 | sc-221607 sc-221607A | 1 mg 5 mg | $63.00 $241.00 | 5 | |
As a CDK inhibitor, it can indirectly influence the activity of Pho85. | ||||||