PHKG1 Activators
PHKG1 Activators are a chemically diverse group of compounds that enhance the activity of Phosphorylase Kinase Catalytic Subunit Gamma 1 (PHKG1), an enzyme that is central to the regulation of glycogen metabolism. This chemical class encompasses various molecules that activate PHKG1 either directly or indirectly through different cellular pathways. Direct activators, such as AMP and Ca2+, bind to PHKG1 or modify its environment in a manner that enhances its catalytic activity. AMP mimics the cellular state of energy depletion, leading to a conformational change in PHKG1 that results in its activation. Ca2+, on the other hand, acts as both a cofactor and a signaling molecule, modulating PHKG1 activity through calcium-dependent pathways. Compounds like A23187 (calcimycin) function by altering intracellular Ca2+ levels, thus indirectly affecting PHKG1 activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine phosphate(Vitamin B8) | 61-19-8 | sc-278678 sc-278678A | 50 g 100 g | $160.00 $240.00 | ||
Activates PHKG1 by mimicking cellular energy depletion. | ||||||
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
Elevates PHKG1 activity by influencing calcium-mediated signaling pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore that can increase intracellular Ca2+ concentration. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cAMP levels, which can activate PKA and subsequently PHKG1. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Inhibits phosphodiesterases leading to increased cAMP and PHKG1 activation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Adrenergic agonist increasing cAMP and subsequently PHKG1 activation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
Analog of cAMP, activates PKA which can lead to PHKG1 activation. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
PPARγ agonist which might influence PHKG1 activity. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Can modulate AMPK activity influencing PHKG1 indirectly. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
AMPK activator which indirectly can enhance PHKG1 activity. | ||||||