PHEX Activators
PHEX Activators encompass a variety of chemical compounds that indirectly augment the functional activity of PHEX, a key enzyme in bone and tooth mineralization. Essential activators like 1,25-Dihydroxyvitamin D3 and Parathyroid Hormone (PTH) play pivotal roles in calcium and phosphate metabolism, integral to PHEX's function. 1,25-Dihydroxyvitamin D3 promotes mineralization and bone remodeling, thereby increasing the demand for PHEX's role in these processes. PTH, by regulating calcium and phosphate levels in the blood, modulates PHEX function in osteoblasts and osteocytes, crucial for bone and tooth development. Fibroblast Growth Factor 23 and Calcitonin also contribute significantly by regulating phosphate homeostasis and calcium metabolism, respectively, influencing PHEX's role in bone matrix mineralization.
Additionally, compounds such as Strontium Ranelate, Calcium Carbonate, Sodium Phosphate, and various bisphosphonates like Alendronate and Risedronate enhance PHEX activity. Strontium Ranelate stimulates bone formation, thus increasing the requirement for PHEX in bone remodeling. Calcium and phosphate supplements provide essential minerals for bone mineralization, where PHEX is critically involved. Alendronate and Risedronate, by inhibiting bone resorption, shift the balance towards bone formation, augmenting the demand for PHEX's function. Teriparatide, a form of parathyroid hormone, further stimulates bone formation, enhancing PHEX activity in bone remodeling. Cinacalcet and Estrogen, by modulating the calcium-sensing receptor and influencing bone density, respectively, also play a role in enhancing PHEX activity. These PHEX Activators, through their targeted effects on bone and tooth mineralization, calcium and phosphate metabolism, and bone remodeling, collectively contribute to the enhancement of PHEX's essential role in maintaining bone integrity and health.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcitonin, Salmon | 47931-85-1 | sc-201167 sc-201167A | 1 mg 5 mg | $154.00 $625.00 | 1 | |
Calcitonin indirectly enhances PHEX activity by modulating calcium and bone metabolism. This hormone's role in lowering blood calcium levels influences PHEX's function in bone mineralization and osteoblast activity. | ||||||
Strontium Ranelate | 135459-87-9 | sc-208403 | 10 mg | $320.00 | ||
Strontium Ranelate indirectly enhances PHEX activity by promoting bone formation and mineralization, processes where PHEX plays a key role. This drug's action in stimulating osteoblast activity increases the requirement for PHEX in bone remodeling. | ||||||
Sodium phosphate | 7601-54-9 | sc-251041 sc-251041A | 25 g 500 g | $42.00 $47.00 | ||
Sodium Phosphate, as a phosphate supplement, indirectly enhances PHEX activity by supplying phosphate, crucial for bone mineralization where PHEX is involved. | ||||||
Parathyroid hormone fragment (1-34) | 52232-67-4 | sc-487943 | 100 µg | $185.00 | ||
Teriparatide, a form of parathyroid hormone, indirectly enhances PHEX activity by stimulating bone formation, thus increasing the functional requirement of PHEX in bone remodeling and mineralization. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estrogen indirectly enhances PHEX activity by influencing bone density and turnover. This hormone’s role in bone health and remodeling processes necessitates the functional involvement of PHEX in maintaining bone integrity. | ||||||