PGT Activators
PGT activators are a class of chemical compounds that have the ability to modulate the activity of the protein known as PGT, which stands for Prostaglandin Transporter. This protein is integral to the cellular transport mechanism for prostaglandins, which are lipid compounds that perform a variety of functions within the body, acting similarly to hormones. Prostaglandins are involved in the regulation of physiological processes such as inflammation and are synthesized at sites of tissue damage or infection, where they cause inflammation, pain, and fever as part of the healing process.
PGT activators work by either directly interacting with the PGT protein to increase its activity or by indirectly affecting mechanisms that enhance PGT's function. Direct activators typically bind to the protein and induce a conformational change that increases its ability to transport prostaglandins across cell membranes. Indirect activators might increase the expression of the PGT protein or promote signaling pathways that lead to enhanced transporter activity. The exact mechanism of action will depend on the specific chemical structure of the activator and its interaction with the protein or associated cellular components. Understanding the science of how PGT activators work and their mechanism of action is essential for research applications. These chemicals are valuable tools for scientists investigating the fundamental role of prostaglandins in cellular processes. By modulating the activity of PGT, researchers can study the transport and regulation of prostaglandins, elucidate their role in various physiological pathways, and explore the broader implications of prostaglandin transport on cellular function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) is a lipid compound that can bind and activate the EP2 and EP4 receptors, which are G protein-coupled receptors (GPCRs). The activation of these receptors leads to the activation of adenylate cyclase and the increase of cyclic AMP (cAMP) levels. The raised cAMP levels activate protein kinase A (PKA), which can phosphorylate and activate PGT. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a labdane diterpene that activates adenylate cyclase, leading to an increase in intracellular cAMP levels. The increased cAMP activates PKA, which then phosphorylates and activates PGT. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases (PDEs), the enzymes that degrade cAMP. By inhibiting PDEs, IBMX increases intracellular cAMP levels, leading to the activation of PKA, which can phosphorylate and activate PGT. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Br-cAMP is a cell-permeable cAMP analog that activates PKA. The activated PKA can then phosphorylate and activate PGT. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a PDE4 inhibitor. By inhibiting PDE4, Rolipram increases intracellular cAMP levels, leading to PKA activation, which can then activate PGT. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine can bind to β-adrenergic receptors, another class of GPCRs. This binding leads to activation of adenylate cyclase and increased cAMP levels, which activate PKA. The activated PKA can then phosphorylate and activate PGT. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective β-adrenergic receptor agonist. Upon binding to β-adrenergic receptors, it stimulates adenylate cyclase and increases cAMP levels, leading to PKA activation. The activated PKA can then phosphorylate and activate PGT. | ||||||
PACAP(6-38) | 137061-48-4 | sc-391136 sc-391136A | 500 µg 1 mg | $529.00 $914.00 | ||
PACAP is a neuropeptide that binds to PACAP receptors, GPCRs that, when activated, stimulate adenylate cyclase, increase cAMP levels, and ultimately activate PKA. The activated PKA can then phosphorylate and activate PGT. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $90.00 $371.00 | 2 | |
Terbutaline is a selective β2-adrenergic receptor agonist. It activates adenylate cyclase via β2-adrenergic receptor stimulation, leading to increased cAMP levels, PKA activation, and subsequent PGT activation. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can bind to D1-like dopamine receptors, which are GPCRs. This binding activates adenylate cyclase, leading to increased cAMP levels. The rise in cAMP activates PKA, which can then phosphorylate and activate PGT. | ||||||