PGs2_5730494M16Rik Activators
TPGS2, also known as Tocopherol Polyethylene Glycol Succinate, is not a protein but rather a synthetic derivative of Vitamin E (α-tocopherol). TPGS2 is commonly used in pharmaceutical formulations and biomedical research due to its unique properties as a surfactant and as an absorption enhancer for drugs with poor solubility. It is particularly valuable in the development of drug delivery systems, including nanoparticles, liposomes, and emulsions.The structure of TPGS2 includes a hydrophilic polyethylene glycol (PEG) chain and a hydrophobic succinate ester linked to the α-tocopherol moiety. Additionally, the α-tocopherol part of the molecule provides the beneficial antioxidant properties of Vitamin E, which can protect drugs from oxidative degradation and enhance the overall stability of pharmaceutical formulations.
In the context of drug delivery, TPGS2 has been shown to facilitate the uptake of drugs by cells, possibly by disrupting the cellular membrane or by enhancing endocytosis. Moreover, TPGS2 has been explored for its potential to reverse multidrug resistance in cancer contexts. It is believed to inhibit the function of P-glycoprotein, a drug efflux pump that reduces the intracellular concentration of agents in resistant cancer cells, thereby enhancing the efficacy of these drugs.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B | 10 g 25 g 100 g | $42.00 $61.00 $138.00 | ||
As the main form of vitamin E, supplementing with alpha-tocopherol could indirectly influence TPGS2 activity by affecting its substrate availability. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Vitamin C can regenerate oxidized vitamin E, potentially affecting the metabolism and function of TPGS2. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
Selenium is a component of antioxidant enzymes and may synergize with vitamin E, potentially affecting TPGS2's role in antioxidant pathways. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 works in conjunction with vitamin E as an antioxidant, potentially influencing TPGS2 activity indirectly. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetylcysteine, as an antioxidant, may influence the oxidative stress environment and indirectly affect TPGS2 function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has antioxidant properties and may influence the cellular redox state, potentially impacting TPGS2 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, known for its antioxidant effects, could indirectly influence TPGS2 by modulating the oxidative stress response. | ||||||
Ferulic acid | 1135-24-6 | sc-204753 sc-204753A sc-204753B sc-204753C sc-204753D | 5 g 25 g 100 g 500 g 1 kg | $42.00 $62.00 $153.00 $552.00 $988.00 | 10 | |
Ferulic Acid is an antioxidant that could potentially affect the metabolism of vitamin E, indirectly influencing TPGS2. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Lipoic Acid, an antioxidant, may impact vitamin E metabolism and thereby influence TPGS2 activity. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $319.00 | ||
Silymarin has antioxidant properties and may indirectly influence TPGS2 by affecting overall antioxidant capacity. | ||||||