PGE synthase 2 Inhibitors
The chemical class PGE synthase 2 Inhibitors refers to a group of compounds that act to reduce the activity of prostaglandin E synthase 2, an enzyme involved in the biosynthesis of prostaglandin E2 (PGE2) from prostaglandin H2 (PGH2). Since there are no direct inhibitors, this class is expanded to include compounds that inhibit the upstream enzyme cyclooxygenase (COX), particularly COX-2. COX-2 is responsible for the production of PGH2, which is the immediate substrate for PGE synthase 2. Therefore, inhibition of COX-2 results in a decrease in PGH2 levels, indirectly reducing the activity ofIt seems there has been a misunderstanding.
There is no protein specifically known as "PGE synthase 2." The confusion likely arises from the naming conventions of enzymes involved in prostaglandin synthesis. COX-2 is often associated with prostaglandin E2 (PGE2) synthesis but is not referred to as PGE synthase 2. Instead, prostaglandin E synthase (PTGES) is the enzyme directly responsible for converting PGH2 to PGE2. There are no well-characterized chemical inhibitors specifically for PTGES, but compounds that inhibit COX-1 and COX-2 would indirectly reduce PTGES's substrate availability, thereby potentially reducing PGE2 synthesis.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vioxx | 162011-90-7 | sc-208486 | 100 mg | $190.00 | 3 | |
Rofecoxib is another selective COX-2 inhibitor, which can decrease PGE2 production by limiting the conversion of arachidonic acid to prostaglandin H2 (PGH2), the immediate substrate for PGE synthase 2. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
Aspirin irreversibly inactivates cyclooxygenase enzymes (COX-1 and COX-2), which can reduce the production of PGH2 and thereby decrease the activity of PGE synthase 2. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin is a non-selective inhibitor of COX-1 and COX-2, which may decrease the availability of PGH2 for PGE synthase 2, thus reducing PGE2 synthesis. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $52.00 $86.00 | 6 | |
Ibuprofen is a non-selective COX inhibitor with a preference for COX-1, which can indirectly limit the production of PGH2 and subsequent PGE2 synthesis potentially involving PGE synthase 2. | ||||||
Naproxen | 22204-53-1 | sc-200506 sc-200506A | 1 g 5 g | $24.00 $40.00 | ||
Naproxen is a non-selective COX inhibitor that may indirectly decrease the activity of PGE synthase 2 by reducing the levels of its substrate, PGH2. | ||||||
Meloxicam | 71125-38-7 | sc-200626 sc-200626A sc-200626B | 20 mg 100 mg 500 mg | $35.00 $92.00 $153.00 | 3 | |
Meloxicam is a preferential COX-2 inhibitor that can reduce PGH2 production, potentially decreasing PGE synthase 2 activity by limiting the availability of its substrate. | ||||||
Piroxicam | 36322-90-4 | sc-200576 sc-200576A | 1 g 5 g | $107.00 $369.00 | 2 | |
Piroxicam is a non-selective COX inhibitor, which may indirectly affect PGE synthase 2 activity by reducing the synthesis of PGH2. | ||||||
Diclofenac acid | 15307-86-5 | sc-357332 sc-357332A | 5 g 25 g | $107.00 $292.00 | 5 | |
Diclofenac is a non-selective COX inhibitor that may reduce the availability of PGH2 for PGE synthase 2, potentially affecting the synthesis of PGE2. | ||||||
Etoricoxib | 202409-33-4 | sc-218446 | 10 mg | $35.00 | 3 | |
Etoricoxib is a selective COX-2 inhibitor that can decrease the production of PGH2, potentially affecting the activity of PGE synthase 2 by reducing the availability of its substrate. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $31.00 $84.00 $147.00 | 3 | |
Sulindac is a prodrug that is metabolized to an active sulfide compound which inhibits COX-1 and COX-2, potentially reducing PGH2 and affecting PGE synthase 2 activity. | ||||||