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Piroxicam (CAS 36322-90-4)

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Alternate Names:
Feldene
Application:
Piroxicam is an inhibitor of prostaglandin synthesis as well as Cox-1 and Cox-2
CAS Number:
36322-90-4
Purity:
≥95%
Molecular Weight:
331.35
Molecular Formula:
C15H13N3O4S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Piroxicam is extensively utilized in research focused on the biochemistry of inflammation. It inhibits cyclooxygenase (COX) enzymes, which are key in the biosynthesis of prostaglandins—lipid compounds that play a central role in inflammation and pain signaling. Research studies employing piroxicam aim to elucidate the enzyme′s role in various inflammatory models, allowing for a detailed understanding of the inflammatory process. The compound′s ability to inhibit COX also makes it a useful tool in cancer research, where it is used to study the effects of prostaglandin inhibition on tumor growth and metastasis. Additionally, piroxicam is applied in comparative analyses of COX inhibition among different compounds to understand their differential impacts on COX-1 and COX-2, enzymes that have distinct physiological roles.


Piroxicam (CAS 36322-90-4) References

  1. [Pharmacokinetic analysis of enterohepatic circulation of piroxicam in rabbits].  |  Zhou, HW., et al. 1992. Zhongguo Yao Li Xue Bao. 13: 180-2. PMID: 1598837
  2. Synthesis and structure analysis of cyclodehydration product of piroxicam: a metabolite detected in dogs and monkeys.  |  Pal, S., et al. 2009. Eur J Med Chem. 44: 3368-71. PMID: 19371981
  3. Piroxicam-induced photosensitivity and contact sensitivity to thiosalicylic acid.  |  Serrano, G., et al. 1990. J Am Acad Dermatol. 23: 479-83. PMID: 2212148
  4. Crystal modifications and dissolution rate of piroxicam.  |  Lyn, LY., et al. 2011. Acta Pharm. 61: 391-402. PMID: 22202198
  5. Solid-state dependent dissolution and oral bioavailability of piroxicam in rats.  |  Lust, A., et al. 2013. Eur J Pharm Sci. 48: 47-54. PMID: 23085546
  6. Effects of dose and sex on the pharmacokinetics of piroxicam in the rat.  |  Roskos, LK. and Boudinot, FD. 1990. Biopharm Drug Dispos. 11: 215-25. PMID: 2328308
  7. Piroxicam inhibits herpes simplex virus type 1 infection in vitro.  |  Astani, A., et al. 2015. Pharmazie. 70: 331-6. PMID: 26062303
  8. Determination of piroxicam from rat articular tissue and plasma based on LC-MS/MS.  |  Kim, HS., et al. 2016. Arch Pharm Res. 39: 1653-1662. PMID: 27752829
  9. Effect of piroxicam on lipid membranes: Drug encapsulation and gastric toxicity aspects.  |  Wilkosz, N., et al. 2017. Eur J Pharm Sci. 100: 116-125. PMID: 28087354
  10. The effect of piroxicam on platelet aggregation.  |  Gaynor, BJ. and Constantine, JW. 1979. Experientia. 35: 797-8. PMID: 467595
  11. Piroxicam, a potent inhibitor of prostaglandin production in cell culture. Structure-activity study.  |  Carty, TJ., et al. 1980. Prostaglandins. 19: 51-9. PMID: 7384538
  12. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.  |  Laneuville, O., et al. 1994. J Pharmacol Exp Ther. 271: 927-34. PMID: 7965814
  13. Crystal forms of piroxicam pivalate: preparation and characterization of two polymorphs.  |  Giordano, F., et al. 1998. J Pharm Sci. 87: 333-7. PMID: 9523987

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Piroxicam, 1 g

sc-200576
1 g
$109.00

Piroxicam, 5 g

sc-200576A
5 g
$376.00