PDIA2 Activators
PDIA2, also known as Protein Disulfide Isomerase A2, is a member of the protein disulfide isomerase (PDI) family, which plays a crucial role in protein folding and quality control within the endoplasmic reticulum (ER) of eukaryotic cells. PDIA2 activators are a class of chemical compounds or molecules that have been identified and developed to modulate the activity of PDIA2. These activators interact specifically with PDIA2 to enhance its enzymatic function, primarily focusing on its isomerase and chaperone activities.
PDIA2 activators typically target the redox-active thioredoxin-like domains within PDIA2, which contain cysteine residues critical for catalyzing disulfide bond formation and rearrangement in proteins. By binding to PDIA2, these activators can influence its conformational changes and stabilize its active state, thus promoting its role in facilitating correct protein folding and disulfide bond formation. This class of compounds has gained significant attention in the field of cellular biology and protein biochemistry due to their potential to modulate PDIA2-mediated processes, which are essential for the proper folding and maturation of numerous secretory and membrane proteins in the ER.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation in the ER, leading to protein misfolding and subsequent ER stress. This could potentially increase the expression of PDIA2. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts ER-to-Golgi protein trafficking, which can cause an accumulation of proteins in the ER, possibly leading to ER stress and increased PDIA2 expression. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-DG inhibits glycolysis, leading to energy deprivation and ER stress. This can potentially result in the upregulation of PDIA2. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
TUDCA is a bile acid that can alleviate ER stress. While it primarily reduces ER stress, it might modulate the expression of some ER-resident proteins including PDIA2. | ||||||
4-Phenylbutyric acid | 1821-12-1 | sc-232961 sc-232961A sc-232961B | 25 g 100 g 500 g | $53.00 $136.00 $418.00 | 10 | |
PBA acts as a chemical chaperone, aiding in proper protein folding. It can mitigate ER stress and might influence the expression of PDIA2 in this context. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
Elevated levels of homocysteine have been linked to ER stress, potentially leading to increased PDIA2 expression. | ||||||
β-Mercaptoethanol | 60-24-2 | sc-202966A sc-202966 | 100 ml 250 ml | $90.00 $120.00 | 10 | |
Similar to DTT, beta-mercaptoethanol is a reducing agent that can disrupt disulfide bonds, leading to potential protein misfolding and ER stress, possibly inducing PDIA2 expression. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that can lead to the accumulation of ubiquitinated proteins, causing ER stress and potentially increasing PDIA2 expression. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that disrupts calcium homeostasis, potentially causing ER stress and increasing PDIA2 expression. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin is an Hsp90 inhibitor. By inhibiting Hsp90, it can lead to the misfolding of its client proteins, causing ER stress and potentially inducing PDIA2 expression. | ||||||