Date published: 2026-4-1

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PDGF-B Inhibitors

Common PDGF-B Inhibitors include, but are not limited to Sunitinib, Free Base CAS 557795-19-4, Dasatinib CAS 302962-49-8, Nilotinib CAS 641571-10-0, Crenolanib CAS 670220-88-9 and Pazopanib Hydrochloride CAS 635702-64-6.

PDGF-B inhibitors belong to a specific chemical class of compounds designed to target and interact with the platelet-derived growth factor B (PDGF-B) protein. PDGF-B is a member of the PDGF family of growth factors that plays a crucial role in cell growth, proliferation, and differentiation. The inhibitors in this class are developed to selectively bind to PDGF-B and modulate its activity, thus influencing its interactions with its receptors and downstream signaling pathways. By interfering with the function of PDGF-B, these inhibitors offer researchers a means to investigate the molecular mechanisms underlying cell growth and tissue development.

The study of PDGF-B inhibitors provides a way to dissect the complex role of PDGF-B in various cellular processes. These inhibitors allow researchers to manipulate PDGF-B signaling and analyze its impact on cell behavior, migration, and proliferation. By perturbing PDGF-B-mediated pathways, scientists can gain insights into its involvement in tissue homeostasis, wound healing, and other physiological processes. The use of PDGF-B inhibitors facilitates a better understanding of the intricate molecular interactions that contribute to normal cellular functions and pathological conditions. Through the investigation of this chemical class, researchers contribute to expanding our knowledge of cellular and molecular biology, uncovering potential targets for future exploration and research endeavors.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Imatinib

152459-95-5sc-267106
sc-267106A
sc-267106B
10 mg
100 mg
1 g
$26.00
$119.00
$213.00
27
(1)

Tyrosine kinase inhibitor targeting PDGF receptors, including PDGF-B receptor. Inhibits autophosphorylation and downstream signaling.

Sunitinib, Free Base

557795-19-4sc-396319
sc-396319A
500 mg
5 g
$153.00
$938.00
5
(0)

Multitargeted tyrosine kinase inhibitor inhibiting PDGF-B receptor autophosphorylation and downstream pathways.

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$70.00
$145.00
51
(1)

Tyrosine kinase inhibitor targeting PDGF-B receptor among others. Competes with ATP for binding, inhibiting autophosphorylation.

Nilotinib

641571-10-0sc-202245
sc-202245A
10 mg
25 mg
$209.00
$413.00
9
(1)

Tyrosine kinase inhibitor inhibiting PDGF-B receptor autophosphorylation and downstream signaling.

Crenolanib

670220-88-9sc-364470
sc-364470A
5 mg
10 mg
$612.00
$1020.00
(1)

Tyrosine kinase inhibitor targeting PDGF receptors, including PDGF-B receptor. Suppresses autophosphorylation and downstream pathways.

Pazopanib Hydrochloride

635702-64-6sc-364564
sc-364564A
10 mg
25 mg
$107.00
$230.00
1
(1)

Multitargeted tyrosine kinase inhibitor affecting PDGF-B receptor and angiogenesis-related signaling.

Regorafenib

755037-03-7sc-477163
sc-477163A
25 mg
50 mg
$320.00
$430.00
3
(0)

Multitargeted tyrosine kinase inhibitor impacting PDGF-B receptor signaling along with angiogenesis and tumor growth pathways.

SU 6668

252916-29-3sc-204309
sc-204309A
10 mg
50 mg
$127.00
$712.00
2
(1)

Tyrosine kinase inhibitor with activity against PDGF-B receptor, VEGF receptor, and FGFR1, suppressing angiogenesis-related signals.