PDGF-B inhibitors belong to a specific chemical class of compounds designed to target and interact with the platelet-derived growth factor B (PDGF-B) protein. PDGF-B is a member of the PDGF family of growth factors that plays a crucial role in cell growth, proliferation, and differentiation. The inhibitors in this class are developed to selectively bind to PDGF-B and modulate its activity, thus influencing its interactions with its receptors and downstream signaling pathways. By interfering with the function of PDGF-B, these inhibitors offer researchers a means to investigate the molecular mechanisms underlying cell growth and tissue development.
The study of PDGF-B inhibitors provides a way to dissect the complex role of PDGF-B in various cellular processes. These inhibitors allow researchers to manipulate PDGF-B signaling and analyze its impact on cell behavior, migration, and proliferation. By perturbing PDGF-B-mediated pathways, scientists can gain insights into its involvement in tissue homeostasis, wound healing, and other physiological processes. The use of PDGF-B inhibitors facilitates a better understanding of the intricate molecular interactions that contribute to normal cellular functions and pathological conditions. Through the investigation of this chemical class, researchers contribute to expanding our knowledge of cellular and molecular biology, uncovering potential targets for future exploration and research endeavors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $26.00 $119.00 $213.00 | 27 | |
Tyrosine kinase inhibitor targeting PDGF receptors, including PDGF-B receptor. Inhibits autophosphorylation and downstream signaling. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $153.00 $938.00 | 5 | |
Multitargeted tyrosine kinase inhibitor inhibiting PDGF-B receptor autophosphorylation and downstream pathways. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Tyrosine kinase inhibitor targeting PDGF-B receptor among others. Competes with ATP for binding, inhibiting autophosphorylation. | ||||||
Nilotinib | 641571-10-0 | sc-202245 sc-202245A | 10 mg 25 mg | $209.00 $413.00 | 9 | |
Tyrosine kinase inhibitor inhibiting PDGF-B receptor autophosphorylation and downstream signaling. | ||||||
Crenolanib | 670220-88-9 | sc-364470 sc-364470A | 5 mg 10 mg | $612.00 $1020.00 | ||
Tyrosine kinase inhibitor targeting PDGF receptors, including PDGF-B receptor. Suppresses autophosphorylation and downstream pathways. | ||||||
Pazopanib Hydrochloride | 635702-64-6 | sc-364564 sc-364564A | 10 mg 25 mg | $107.00 $230.00 | 1 | |
Multitargeted tyrosine kinase inhibitor affecting PDGF-B receptor and angiogenesis-related signaling. | ||||||
Regorafenib | 755037-03-7 | sc-477163 sc-477163A | 25 mg 50 mg | $320.00 $430.00 | 3 | |
Multitargeted tyrosine kinase inhibitor impacting PDGF-B receptor signaling along with angiogenesis and tumor growth pathways. | ||||||
SU 6668 | 252916-29-3 | sc-204309 sc-204309A | 10 mg 50 mg | $127.00 $712.00 | 2 | |
Tyrosine kinase inhibitor with activity against PDGF-B receptor, VEGF receptor, and FGFR1, suppressing angiogenesis-related signals. | ||||||