PDE8B Activators
Phosphodiesterase 8B (PDE8B) activators represent a class of chemical compounds that target a specific enzyme in the human body known as PDE8B. PDE8B is a member of the phosphodiesterase enzyme family, which plays a crucial role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). These cyclic nucleotides are second messengers that mediate various cellular signaling pathways. PDE8B, in particular, is responsible for the degradation of cAMP and cGMP, ultimately affecting multiple physiological processes. PDE8B activators are designed to enhance the activity of this enzyme, thereby modulating the levels of cAMP and cGMP in specific cellular contexts.
The mechanism of action of PDE8B activators primarily involves inhibiting the enzymatic activity of PDE8B, leading to increased intracellular levels of cAMP and cGMP. This, in turn, can have far-reaching effects on various cellular processes. While the full spectrum of functions influenced by PDE8B activation is still an active area of research, it is known that cAMP and cGMP are involved in regulating processes such as neurotransmission, hormone signaling, and smooth muscle relaxation. Thus, PDE8B activators have the potential to impact these processes by increasing the levels of these cyclic nucleotides.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, directly increasing cAMP production, which can lead to the indirect activation of PDE8B that regulates cAMP levels. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Activates beta-adrenergic receptors, stimulating adenylate cyclase and directly increasing cAMP levels. Elevated cAMP levels may indirectly activate PDE8B, responsible for cAMP regulation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Binds to its receptors, directly activating adenylate cyclase to increase cAMP levels, potentially indirectly activating PDE8B, involved in cAMP degradation. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Directly influences cAMP levels through specific receptor subtypes in certain contexts, potentially indirectly activating PDE8B involved in cAMP regulation. | ||||||
Glucagon trifluoroacetic acid salt | 9007-92-5 (free base) | sc-495801 | 1 mg | $480.00 | ||
Activates adenylate cyclase in the liver, directly increasing cAMP levels, which may indirectly activate PDE8B, modulating cAMP levels. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Directly impacts cAMP levels through adenosine receptors in specific cell types, potentially indirectly affecting PDE8B, which regulates cAMP levels. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Acts on alpha and beta-adrenergic receptors, directly impacting cAMP levels and potentially indirectly activating PDE8B, playing a role in cAMP regulation. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $520.00 | 3 | |
Serotonin receptors directly influence cAMP signaling in specific cell types, potentially indirectly activating PDE8B, which regulates cAMP levels. | ||||||