PDE7A Activators

PDE7A Activators are a class of chemical compounds that can enhance the functional activity of PDE7A, a cAMP-specific phosphodiesterase. The functional activity of PDE7A is enhanced when the intracellular levels of cAMP are increased. This increase can be achieved by inhibiting other PDE isozymes that degrade cAMP. For instance, IBMX, a non-specific PDE inhibitor, and Rolipram, a PDE4 inhibitor, can increase cAMP levels by inhibiting the degradation of cAMP by other PDE isozymes. The increased cAMP levels indirectly enhance the functional activity of PDE7A as it has more substrate to degrade.

Similarly, PDE5 inhibitors like Sildenafil, Dipyridamole, Tadalafil, and Vardenafil increase cGMP levels. The elevated cGMP levels can cause a compensatory increase in cAMP degradation, indirectly enhancing PDE7A activity. Zardaverine, Milrinone, Cilostazol, and Enoximone are PDE3 inhibitors that increase cAMP levels by inhibiting PDE3, another cAMP-degrading isozyme. The increased cAMP levels indirectly enhance the functional activity of PDE7A. Vinpocetine, a PDE1 inhibitor, also enhances PDE7A activity by increasing cAMP levels. Papaverine, a non-specific PDE inhibitor, promotes the accumulation of cAMP, providing more substrate for PDE7A to degrade, thereby enhancing its activity.