PCDHB3 Inhibitors
Inhibitors of PCDHB3 function through a variety of mechanisms that indirectly lead to the decreased activity of this membrane protein. Some compounds achieve this by altering the composition and properties of the cell membrane itself. For instance, changes in membrane fluidity and the composition of lipid microdomains can significantly impact the localization and activity of PCDHB3, as this protein's function is closely tied to its environment within the cellular membrane. Specific inhibitors that extract cholesterol or integrate fatty acids into the membrane can modify the structural context in which PCDHB3 operates, potentially diminishing its function. Additionally, by modulating the levels of critical ions and cofactors such as calcium and magnesium, or the availability of pivotal signaling lipids, the conformational state and adhesive properties of PCDHB3 can be affected, leading to an overall reduction in its functional activity.
Other inhibitors work by targeting intracellular signaling cascades that regulate PCDHB3's activity. These compounds inhibit key enzymes or alter secondary messenger concentrations, thereby affecting the phosphorylation states and interactions of proteins that govern PCDHB3's signaling roles. For example, inhibition of protein kinases or interference with calcium-calmodulin-dependent processes results in a disruption of the post-translational modifications that are essential for PCDHB3's proper functioning. This can lead to its mislocalization, degradation, or the inability to interact with other proteins within the cell membrane complexes. Furthermore, agents that modulate G-protein coupled receptor (GPCR) signaling pathways can impact the downstream effects that regulate PCDHB3, either through direct interactions or by influencing the broader signaling environment of the cell. In addition, the manipulation of proteolytic systems within the cell, such as the ubiquitin-proteasome pathway, could lead to an increased rate of PCDHB3 turnover, thereby reducing its presence and activity at the cell surface.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
By incorporating into the cell membrane, this compound can alter membrane fluidity and signaling, indirectly leading to modulation of membrane proteins like PCDHB3, potentially reducing their functional activity at the cell surface. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Elevating extracellular calcium concentration can influence calcium-dependent adhesion molecules, including PCDHB3, causing conformational changes that may reduce their adhesive properties and downstream signaling. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $46.00 $69.00 $163.00 $245.00 $418.00 | 3 | |
As a cofactor for various enzymes, changes in magnesium levels can affect signaling pathways and cellular processes, indirectly influencing the activity of membrane proteins like PCDHB3 by altering their local environment or the state of associated proteins. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
This compound is integral to membrane structure and can modulate the fluidity and microdomain composition. These changes can influence the localization and function of membrane proteins such as PCDHB3, likely leading to decreased activity. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $20.00 $48.00 $160.00 $82.00 | 19 | |
Extracting cholesterol from cell membranes, this compound disrupts lipid rafts, which are critical for the function of many signaling proteins, including PCDHB3, potentially resulting in diminished protein activity. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $343.00 $1642.00 | 20 | |
As an inhibitor of protein kinase C (PKC), this compound can dampen PKC-mediated signaling, which may indirectly influence the function of PCDHB3 by affecting phosphorylation states and interactions of proteins that modulate its activity. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
By inhibiting calmodulin, this compound can interfere with calcium-calmodulin dependent processes, which could indirectly lead to a decrease in the functional activity of PCDHB3 by altering signaling pathways that regulate its action. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
As a tyrosine kinase inhibitor, this compound can reduce the phosphorylation of proteins involved in cell signaling. This action may indirectly inhibit the activity of PCDHB3 by affecting the signaling pathways and interactions it is involved with. | ||||||
Gadolinium(III) chloride | 10138-52-0 | sc-224004 sc-224004A | 5 g 25 g | $153.00 $357.00 | 4 | |
Can block certain ion channels and alter cellular signaling. Such disruptions may indirectly inhibit PCDHB3 by affecting the ion homeostasis and signaling pathways that influence its function and localization. | ||||||