PATE Inhibitors
PATE inhibitors are a class of chemical compounds designed to modulate the activity of PATE proteins, which stands for Prostate And Testis Expressed proteins. These proteins are part of a gene family predominantly expressed in reproductive tissues such as the prostate and testis. PATE proteins are believed to play significant roles in reproductive biology, including processes like sperm maturation and fertilization. By inhibiting the function of PATE proteins, researchers aim to study their specific roles within cellular mechanisms and understand the molecular pathways they influence. These inhibitors may work by binding to active sites on the PATE proteins, preventing them from interacting with other molecules, or by altering their structural conformation, thus affecting their biological activity.
The development of PATE inhibitors involves identifying and designing molecules that can selectively target PATE proteins with high specificity and affinity. This process may utilize techniques such as molecular modeling, high-throughput screening, and structure-activity relationship studies to discover and optimize potential inhibitory compounds. Chemically, these inhibitors could be small molecules, peptides, or other biologically active agents capable of interfering with the function of PATE proteins. By employing PATE inhibitors in experimental settings, scientists can dissect the roles of these proteins in cellular processes, contributing to a deeper understanding of reproductive biology and the complex regulatory networks within reproductive tissues. This research enhances knowledge about the fundamental mechanisms governing cell signaling and function in the context of reproductive health.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
This histone deacetylase inhibitor can remodel chromatin structures, thereby potentially downregulating gene expression including PATE by altering transcriptional environments. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound disrupts DNA methylation patterns, potentially leading to the silencing of specific gene promoters. It may decrease PATE expression by altering promoter methylation states. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid suppresses histone deacetylases, which can lead to the downregulation of gene expression through changes in chromatin structure and histone modification states, potentially including PATE. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate reduces gene expression by increasing histone acetylation levels, which might lead to the downregulation of genes such as PATE through modifications in chromatin accessibility. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid can reshape gene expression landscapes by promoting cellular differentiation, which may include the downregulation of the PATE gene in specific cellular contexts. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
This mTOR inhibitor decreases protein synthesis and cell growth, which could lead to the reduced expression of target proteins including PATE by suppressing translational initiation processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 inhibits the PI3K pathway, leading to decreased survival signals and potentially causing a reduction in the expression of survival-related proteins, including PATE. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can lead to the downregulation of gene expression by altering the activity of specific transcription factors and histone modifications, thereby potentially decreasing PATE expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol decreases gene expression by interacting with sirtuins and modifying signaling pathways, which could lead to a reduction in proteins such as PATE by altering transcriptional activity. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits protein synthesis directly at the level of translation elongation, leading to a decrease in the synthesis of rapidly produced proteins like PATE. | ||||||