PARP S Inhibitors
PARP S inhibitors belong to a specialized class of chemical compounds designed to target the PARP S (Poly(ADP-ribose) polymerase S) protein. Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes involved in various cellular processes, including DNA repair and maintenance of genomic stability. Among the many PARP family members, PARP S represents a distinct subgroup that is characterized by its unique structural and functional properties. While the exact roles and functions of PARP S are still being elucidated, it is believed to play a role in the regulation of post-translational modifications of proteins through the addition of poly(ADP-ribose) chains.
Inhibitors targeting PARP S are designed to interact with the protein and modulate its activity, influencing the processes in which it is involved. The precise mechanisms of action of these inhibitors are subjects of ongoing research, but they are expected to disrupt the enzymatic activity of PARP S, which is critical for its role in protein modification. Research into PARP S inhibitors is primarily focused on understanding the intricate molecular pathways associated with this specific PARP variant, as well as its contributions to cellular functions and regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
A known PARP inhibitor, could downregulate PARP expression through feedback inhibition by blocking its enzymatic activity. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
As an amide form of vitamin B3, it may compete with NAD+, reducing PARP activity and possibly its expression due to feedback. | ||||||
3-Aminobenzamide | 3544-24-9 | sc-3501 sc-3501B sc-3501A | 100 mg 1 g 5 g | $15.00 $37.00 $52.00 | 18 | |
An inhibitor of PARP's enzymatic activity, could also lead to reduced expression through feedback mechanisms. | ||||||
Veliparib | 912444-00-9 | sc-394457A sc-394457 sc-394457B | 5 mg 10 mg 50 mg | $182.00 $275.00 $726.00 | 3 | |
Another PARP inhibitor that may cause decreased expression of PARP by inhibiting its activity and triggering compensatory pathways. | ||||||
Rucaparib | 283173-50-2 | sc-507419 | 5 mg | $150.00 | ||
Targets PARP enzymatic function; may also affect its expression through cellular regulatory feedback. | ||||||
PARP Inhibitor VIII, PJ34 | 344458-15-7 | sc-204161 sc-204161A | 1 mg 5 mg | $58.00 $142.00 | 20 | |
A potent PARP inhibitor that could theoretically lead to decreased PARP expression through inhibition of its activity. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
While primarily a Wnt pathway inhibitor, it may indirectly affect PARP expression by modulating related signaling pathways. | ||||||
AG14361 | 328543-09-5 | sc-483192 | 5 mg | $255.00 | ||
A selective inhibitor of PARP, could reduce PARP expression through cellular feedback mechanisms. | ||||||