PARD6B Activators
PARD6B activators belong to a class of chemical compounds designed to interact with and modulate the activity of the Par-6 Family Cell Polarity Regulator Beta (PARD6B) protein. PARD6B is a member of the Par protein family, which plays a fundamental role in establishing and maintaining cellular polarity in a wide range of organisms. Cellular polarity is essential for various biological processes, including cell division, migration, and differentiation. PARD6B itself is involved in the formation and maintenance of cell-cell junctions, particularly adherens junctions, which are critical for tissue integrity and the regulation of intercellular communication.
The mechanism of action of PARD6B activators typically involves their interaction with the PARD6B protein, often targeting specific domains or regions that are crucial for its function. By binding to PARD6B, these compounds can modulate its activity, influencing its ability to participate in the protein complexes responsible for establishing and maintaining cell polarity. This modulation may lead to changes in cell morphology, migration, and adhesion, as well as alterations in the organization of cellular structures such as the actin cytoskeleton. Researchers are actively investigating the molecular details of PARD6B activation and its downstream effects to gain a deeper understanding of how cellular polarity is regulated and how it impacts various cellular processes and physiological contexts, contributing to our knowledge of cell biology and tissue development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ZCL278 | 587841-73-4 | sc-507369 | 10 mg | $115.00 | ||
ZCL278 is a selective Cdc42 GTPase inhibitor that can indirectly affect PARD6B activity by modulating Cdc42, which is closely associated with the Par complex. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
NSC23766 inhibits Rac1 activation by preventing its interaction with specific guanine nucleotide exchange factors (GEFs), indirectly influencing PARD6B activity through the Rac1 pathway. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a potent, selective, and reversible inhibitor of Cdc42 GTPase, affecting PARD6B by altering Cdc42 activity and its downstream signaling pathways. | ||||||
CASIN | 425399-05-9 | sc-397016 | 10 mg | $460.00 | 1 | |
CASIN inhibits Cdc42 activity, leading to altered cell polarity and cytoskeletal dynamics, thereby indirectly influencing PARD6B through Cdc42 pathways. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $213.00 $889.00 | 12 | |
EHT 1864 is a potent Rac1 inhibitor that affects PARD6B activity indirectly by modulating Rac1 signaling pathways. | ||||||
ITX 3 | 347323-96-0 | sc-295214 sc-295214A | 10 mg 50 mg | $145.00 $615.00 | ||
ITX3 is a small molecule inhibitor of Trio, a guanine nucleotide exchange factor for Rac1, thus indirectly influencing PARD6B via the Rac1 pathway. | ||||||
AZA1 | 1071098-42-4 | sc-507497 | 10 mg | $600.00 | ||
AZA1 is a Rac1 inhibitor that can indirectly modulate PARD6B activity through the Rac1 signaling pathway. | ||||||
Rhosin | 1173671-63-0 | sc-507401 | 25 mg | $555.00 | ||
Rhosin inhibits the interaction between RhoA and its GEFs, potentially affecting PARD6B activity indirectly via related signaling pathways. | ||||||