PAP-α Inhibitors
The inhibitors listed above primarily target processes upstream of polyadenylation, such as transcription and RNA processing, which could indirectly influence PAP-α activity. Given PAP-α's critical role in RNA maturation, modulation of these upstream processes is relevant for understanding its function and potential regulation. Cordycepin and Actinomycin D can directly affect RNA synthesis and processing, potentially impacting the substrates available for PAP-α. α-Amanitin, DRB, and compounds inhibiting RNA polymerase II or III would decrease the synthesis of RNA substrates for PAP-α.
Flavopiridol and Triptolide, by inhibiting factors involved in transcriptional elongation and initiation, might indirectly affect PAP-α activity. Leptomycin B and Selinexor, affecting nuclear export, could indirectly influence the dynamics of RNA substrates processed by PAP-α. CX-5461, by inhibiting RNA Polymerase I, might influence ribosomal RNA synthesis, thereby indirectly affecting PAP-α's role in mRNA processing. Spliceosome inhibitors like Meayamycin B and Pladienolide B could impact the maturation of pre-mRNA substrates for PAP-α.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Cordycepin, an adenosine analog, can inhibit polyadenylation and potentially affect PAP-α activity by prematurely terminating poly(A) tail synthesis. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin, an inhibitor of RNA polymerase II, can affect the transcription of RNAs that are substrates for PAP-α. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA polymerase, potentially impacting PAP-α activity by reducing RNA substrate availability. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB inhibits RNA polymerase II, thereby potentially reducing the number of RNA substrates available for PAP-α. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
Flavopiridol inhibits CDK9, a component of the positive transcription elongation factor b (P-TEFb), potentially affecting RNA polymerase II activity and indirectly PAP-α function. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide inhibits the XPB subunit of TFIIH and can impair transcription, potentially affecting PAP-α activity. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Leptomycin B inhibits nuclear export, which might indirectly affect the function of PAP-α by altering RNA processing dynamics. | ||||||
CX-5461 | 1138549-36-6 | sc-507275 | 5 mg | $245.00 | ||
CX-5461 inhibits RNA Polymerase I, thereby potentially affecting ribosomal RNA synthesis and indirectly influencing PAP-α's role in mRNA processing. | ||||||
KPT 330 | 1393477-72-9 | sc-489062 | 5 mg | $173.00 | ||
Selinexor inhibits exportin-1 (XPO1), potentially impacting nuclear export of mRNAs processed by PAP-α. | ||||||
AM 580 | 102121-60-8 | sc-203505 sc-203505A | 5 mg 25 mg | $99.00 $390.00 | 2 | |
This compound inhibits RNA polymerase II and III, potentially reducing the substrate availability for PAP-α. | ||||||