Palladin inhibitors are a class of chemical compounds that have garnered significant attention in the field of molecular biology and cellular research. These inhibitors target palladin, a protein that plays a pivotal role in cytoskeletal organization and cell motility. Palladin itself is an actin-associated protein, and it is primarily found in cells with dynamic cytoskeletal structures, such as muscle cells, fibroblasts, and neurons. The discovery of palladin inhibitors has opened up new avenues for studying the fundamental processes governing cell morphology, motility, and migration.
These inhibitors are designed to specifically interact with palladin, disrupting its normal functions within the cell. Palladin is known to regulate actin dynamics and act as a scaffold protein, contributing to the formation of cellular structures like stress fibers and focal adhesions. By inhibiting palladin, researchers can investigate its precise role in these processes and gain deeper insights into the molecular mechanisms that underlie cell shape changes and motility.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Inhibits ROCK kinase, which is involved in actin cytoskeleton remodeling, thus indirectly influencing palladin's function. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Inhibits myosin II ATPase activity, affecting cell contractility and thereby influencing palladin's role in maintaining cell shape. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
Inhibits ARP2/3 complex-mediated actin nucleation, affecting the formation of branched actin networks where palladin may localize. | ||||||
NVP-BHG712 | 940310-85-0 | sc-364554 sc-364554A | 5 mg 50 mg | $232.00 $1764.00 | ||
Inhibits formin-mediated actin nucleation and elongation, affecting actin structures and potentially palladin's associated functions. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Inhibits the N-WASP-Arp2/3 pathway, affecting actin polymerization and indirectly palladin's role in actin cytoskeleton organization. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Stabilizes actin filaments in a state that is less favorable for branching and network formation, indirectly affecting palladin's role in actin dynamics. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Binds and stabilizes actin filaments, affecting the dynamic turnover of the cytoskeleton and hence palladin's role in these processes. | ||||||