PAK4 Activators
PAK4 activators represent a class of chemical compounds designed to interact with and modulate the activity of the protein kinase P21-Activated Kinase 4 (PAK4). PAK4 is a member of the PAK family, which is a group of serine/threonine kinases known for their critical roles in intracellular signaling pathways involved in cell growth, motility, and survival. PAK4, in particular, has garnered attention for its involvement in various cellular processes, including cytoskeletal dynamics, cell adhesion, and cell proliferation. PAK4 activators are engineered to influence the regulatory mechanisms governing PAK4 function, thus affecting its downstream signaling pathways.
The mechanism of action of PAK4 activators typically involves their interaction with PAK4, either by binding to specific domains within the kinase or by altering its conformation and activation state. By doing so, these compounds can modulate the kinase activity of PAK4, which in turn can lead to various cellular responses. These responses may include changes in cell morphology, migration, and proliferation, as well as alterations in signaling pathways related to cancer, development, and other cellular processes. Researchers continue to investigate the molecular details of PAK4 activation and its impact on intracellular signaling, shedding light on its significance in cellular physiology and uncovering new insights into cell biology and disease mechanisms.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a potent activator of PAK4 through the activation of the JNK signaling pathway, indirectly promoting PAK4 activity. | ||||||
2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester | 305834-79-1 | sc-479756 | 25 mg | $380.00 | ||
SC-79 (2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester) specifically activates AKT, which in turn can activate PAK4 through downstream signaling pathways, thus indirectly enhancing PAK4 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can lead to the activation of PAK4 through cAMP-dependent protein kinase A (PKA) pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Protein Kinase C (PKC) which can subsequently activate PAK4 through PKC-dependent pathways. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates AMPK, which can lead to the activation of PAK4 in metabolic pathways and stress response mechanisms. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, activates PKA and can indirectly lead to PAK4 activation through PKA-dependent signaling. | ||||||
1-Oleoyl lysophosphatidic acid | 65528-98-5 | sc-222720 sc-222720A sc-222720B sc-222720C | 1 mg 5 mg 10 mg 25 mg | $32.00 $142.00 $250.00 $541.00 | 11 | |
1-Oleoyl lysophosphatidic acid activates its receptor, leading to downstream signaling that involves PAK4 activation, particularly in cell migration and proliferation processes. | ||||||