PADI6 Inhibitors
PADI6 inhibitors are a specialized class of chemical compounds that target and inhibit the enzyme Peptidylarginine Deiminase 6 (PADI6). PADI6 is one of the five isoforms of the peptidylarginine deiminase family, which are involved in the post-translational modification of proteins through the process of citrullination. This process involves the conversion of arginine residues in proteins to citrulline, a modification that can significantly influence protein function, interactions, and stability. PADI6 is particularly noted for its role in early embryonic development and oocyte maturation, where it contributes to the regulation of protein citrullination patterns essential for these processes.
Inhibitors of PADI6 are designed to specifically obstruct the enzymatic activity of PADI6 by binding to its active site or otherwise interfering with its function. These inhibitors can vary widely in their chemical structures and mechanisms of action but are united by their ability to selectively inhibit PADI6 activity. By blocking PADI6, these inhibitors prevent the citrullination of target proteins, thus altering the functional dynamics of proteins that are substrates for this enzyme. The study of PADI6 inhibitors helps in understanding the role of citrullination in developmental biology and cellular processes, providing insights into the specific functions of PADI6 and its impact on cellular and molecular mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Streptonigrin | 3930-19-6 | sc-500892 sc-500892A | 1 mg 5 mg | $104.00 $364.00 | 1 | |
Streptonigrin inhibits Protein-arginine deiminase type-6 indirectly by generating reactive oxygen species upon reduction. These reactive oxygen species can modify cysteine residues, including the active site cysteine of the enzyme, thereby inhibiting its catalytic activity. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram inhibits Protein-arginine deiminase type-6 by binding to the thiol groups present in the active site of the enzyme. This interaction leads to the inactivation of the enzyme's catalytic function because disulfiram can form a disulfide bond with the active site cysteine, blocking the enzyme's ability to interact with its substrates. | ||||||
NSC 95397 | 93718-83-3 | sc-203654 sc-203654A | 10 mg 50 mg | $255.00 $847.00 | 9 | |
NSC 95397 inhibits Protein-arginine deiminase type-6 by covalently modifying the active site cysteine residue. This irreversible binding prevents the enzyme from catalyzing the deimination of arginine residues, thereby inhibiting its function. | ||||||
AMI-1, sodium salt | 20324-87-2 | sc-205928 sc-205928A | 5 mg 25 mg | $114.00 $398.00 | 2 | |
AMI-1 inhibits Protein-arginine deiminase type-6 by binding to the enzyme in a manner that interferes with substrate recognition and processing. | ||||||