Date published: 2026-4-25

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p63 Activators

p63 activators are molecules that specifically target and enhance the activity of the protein p63, a member of the p53 family of transcription factors that includes p53, p63, and p73. The p63 protein plays a pivotal role in the development and maintenance of epithelial tissues, as well as in the regulation of cell cycle and apoptosis. It exists in multiple isoforms due to alternative promoter usage and splicing, with the two major categories being the transactivation domain-containing (TAp63) and the N-terminally truncated (∆Np63) isoforms. These isoforms can act as transcriptional activators or repressors, depending on the cellular context. The activity of p63 is tightly controlled at multiple levels, including transcription, post-translational modifications, and protein-protein interactions. p63 activators can modulate the activity of this transcription factor by affecting these regulatory mechanisms, ultimately leading to changes in the expression of target genes that are crucial for cellular differentiation, proliferation, and survival. Chemically, p63 activators are varied and may include small molecules, peptides, or natural bioactive compounds. These activators may interact directly with p63, stabilizing its active form or promoting its binding to DNA and recruitment of coactivators, thereby enhancing its transcriptional activity. Alternatively, some p63 activators might function indirectly by inhibiting negative regulators of p63 or by modifying signaling pathways that converge on p63, leading to its activation. For instance, molecules that modify the phosphorylation, acetylation, or ubiquitination status of p63 can potentially act as p63 activators by influencing its stability, localization, or interaction with other cellular components.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid activates p63 by binding to retinoic acid receptors (RARs) and subsequently influencing p63 transcription. This activation plays a role in regulating epithelial cell differentiation and development.

1α,25-Dihydroxyvitamin D3

32222-06-3sc-202877B
sc-202877A
sc-202877C
sc-202877D
sc-202877
50 µg
1 mg
5 mg
10 mg
100 µg
$220.00
$645.00
$1000.00
$1500.00
$440.00
32
(2)

Calcitriol, the active form of vitamin D, activates p63 through vitamin D receptors (VDRs). This activation contributes to the modulation of keratinocyte differentiation and maintenance of epithelial tissue integrity.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$152.00
$479.00
$632.00
$1223.00
$2132.00
33
(3)

Trichostatin A, a histone deacetylase (HDAC) inhibitor, activates p63 by preventing the deacetylation of histones associated with the p63 gene. This activation influences gene expression, promoting epithelial cell fate.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol activates p63 by enhancing SIRT1 activity. The interaction between resveratrol, SIRT1, and p63 influences epithelial cell differentiation and cellular processes associated with p63-mediated signaling.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$153.00
$292.00
$489.00
$1325.00
$8465.00
$933.00
22
(1)

Sulforaphane activates p63 indirectly through NRF2-dependent pathways. This activation supports the antioxidant response and cellular processes that contribute to p63-mediated signaling in epithelial tissues.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

EGCG, a polyphenol from green tea, activates p63 through mechanisms involving the modulation of cellular redox status. This activation influences the regulation of epithelial cell differentiation and tissue development.

Mithramycin A

18378-89-7sc-200909
1 mg
$55.00
6
(1)

Mithramycin, a DNA-binding antibiotic, activates p63 by binding to specific DNA sequences associated with p63 gene expression. This activation modulates transcriptional processes involved in epithelial cell development.

Pifithrin-α hydrobromide

63208-82-2sc-45050
sc-45050A
5 mg
25 mg
$120.00
$300.00
36
(1)

Pifithrin-α(HBr), a p53 inhibitor, indirectly activates p63 by preventing the inhibition of p63 by p53. This activation contributes to the modulation of cellular processes involving p63-mediated signaling in epithelial tissues.

I-BET 151 Hydrochloride

1300031-49-5 (non HCl Salt)sc-391115
10 mg
$450.00
2
(0)

I-BET151, a BET bromodomain inhibitor, activates p63 by influencing chromatin structure. This activation modulates transcriptional processes associated with epithelial cell differentiation and tissue development.

Z-VAD-FMK

187389-52-2sc-3067
500 µg
$75.00
256
(6)

Z-VAD-FMK, a pan-caspase inhibitor, activates p63 by preventing caspase-mediated degradation. This activation influences p63 stability and activity, contributing to the regulation of epithelial cell fate and tissue homeostasis.