1α,25-Dihydroxyvitamin D3 (CAS 32222-06-3)

4.5(2)

Alternate Names: 1α,25-Dihydroxyvitamin D3 also known as Calcitriol; 1α,25-Dihydroxycholecalciferol; Topitriol; Soltriol; Vitamin D3, 1α,25-Dihydroxy-, Dihydroxycholecalciferol; Calcitriol-D6; 5- {2- [1- (5- Hydroxy- 1,5- dimethyl- hexyl)- 7a- methyl- octahydro- inden- 4- ylidene]- ethylidene}- 4- methylene- cyclohexane- 1,3- diol(1,25- Dihydroxyvitamin D3, Calcitriol); (1,25- Dihydroxyvitamin D3, Calcitriol)

Application 1α,25-Dihydroxyvitamin D3 is also known as Calcitriol, the active form of vitamin D₃, and an activator of PKC and VDR

CAS 등록번호: 32222-06-3

순도: ≥95%

분자량: 416.64

분자식: C₂₇H₄₄O₃

추가 정보: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

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1α,25-Dihydroxyvitamin D₃ (Calcitriol) is a metabolite of the secosteroid vitamin D₃. 1α,25-Dihydroxyvitamin D3 is a hormone that stimulates intestinal calcium transport at a much higher rate than vitamin D₃ and hydroxy D₃, and 1α,25-Dihydroxyvitamin D3 is considered to represent the biologically active form of vitamin D₃. In addition to regulating the movement of calcium in the blood and bone, 1α,25-Dihydroxyvitamin D₃ participates in developmental regulation and signaling. It stimulates an increase in protein kinase C levels with an effect on the regulation of c-myc transcription and activation of Raf kinase. 1α,25-Dihydroxyvitamin D₃ is shown to increase the synthesis of prostacyclin with a correlated increase in cyclooxygenase activity, indicating a further role in vascular regulation. 1α,25-Dihydroxyvitamin D3 (Calcitriol) is an activator of PKC and VDR. 1α,25-Dihydroxyvitamin D3 has a widespread effect on cellular differentiation and proliferation, central nervous system function and can modulate immune responsiveness.

References

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3. Simpson, R.U., et al. 1989. J. Biol. Chem. 264: 19710-19715. PMID: 2684961

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Physical State :

Solid

용해도 :

Soluble in ethanol (83 mg/ml at 25° C), DMSO (83 mg/ml at 25° C), methanol, and chloroform.

저장 :

Store at -20° C

비등점 :

~565.0° C at 760 mmHg (Predicted)

밀도 :

~1.1 g/cm³ (Predicted)

굴절률 :

n²⁰_D 1.55 (Predicted)