Sorry, it seems JavaScript is not enabled in your browser. Please enable it to get the best site experience.

1α,25-Dihydroxyvitamin D3 | CAS 32222-06-3 | SCBT - Santa Cruz Biotechnology
1α,25-Dihydroxyvitamin D3 CAS: 32222-06-3
MF: C27H44O3
MW: 416.64

1α,25-Dihydroxyvitamin D3 (CAS 32222-06-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 108ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
1α,25-Dihydroxyvitamin D3 is rated 4.5 out of 5 by 2.
loading
5
1
4
1
3
0
2
0
1
0
Alternate Names: 1α,25-Dihydroxyvitamin D3 also known as Calcitriol; 1α,25-Dihydroxycholecalciferol; Topitriol; Soltriol; Vitamin D3, 1α,25-Dihydroxy-, Dihydroxycholecalciferol; Calcitriol-D6; 5- {2- [1- (5- Hydroxy- 1,5- dimethyl- hexyl)- 7a- methyl- octahydro- inden- 4- ylidene]- ethylidene}- 4- methylene- cyclohexane- 1,3- diol(1,25- Dihydroxyvitamin D3, Calcitriol); (1,25- Dihydroxyvitamin D3, Calcitriol)
Application 1α,25-Dihydroxyvitamin D3 is also known as Calcitriol, the active form of vitamin D3, and an activator of PKC and VDR
CAS 등록번호: 32222-06-3
순도: ≥95%
분자량: 416.64
분자식: C27H44O3
추가 정보: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).
loading

1α,25-Dihydroxyvitamin D3 (Calcitriol) is a metabolite of the secosteroid vitamin D3. 1α,25-Dihydroxyvitamin D3 is a hormone that stimulates intestinal calcium transport at a much higher rate than vitamin D3 and hydroxy D3, and 1α,25-Dihydroxyvitamin D3 is considered to represent the biologically active form of vitamin D3. In addition to regulating the movement of calcium in the blood and bone, 1α,25-Dihydroxyvitamin D3 participates in developmental regulation and signaling. It stimulates an increase in protein kinase C levels with an effect on the regulation of c-myc transcription and activation of Raf kinase. 1α,25-Dihydroxyvitamin D3 is shown to increase the synthesis of prostacyclin with a correlated increase in cyclooxygenase activity, indicating a further role in vascular regulation. 1α,25-Dihydroxyvitamin D3 (Calcitriol) is an activator of PKC and VDR. 1α,25-Dihydroxyvitamin D3 has a widespread effect on cellular differentiation and proliferation, central nervous system function and can modulate immune responsiveness.


References

1. Mangelsdorf, D.J., et al. 1984. J. Cell Biol. 98: 391-398. PMID: 6319426

2. Carthy, E.P., et al. 1989. Hypertension. 13: 954-959. PMID: 2786849

3. Simpson, R.U., et al. 1989. J. Biol. Chem. 264: 19710-19715. PMID: 2684961

4. Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166: 916-923. PMID: 2405860

5. Wakasugi, M., et al. 1991. Prostaglandins. 42: 127-136. PMID: 1775635

6. Lissoos, T.W., et al. 1993. J. Biol. Chem. 268: 25132-25138. PMID: 8227076

7. de Boland, A.R., et al. 1994. J. Biol. Chem. 269: 8675-8679. PMID: 8132595

8. Morrison, N.A., et al. 1994. Nature. 367: 284-287. PMID: 8161378

9. Slater, S.J., et al. 1995. J. Biol. Chem. 270: 6639-6643. PMID: 7896803

Physical State :
Solid
용해도 :
Soluble in ethanol (83 mg/ml at 25° C), DMSO (83 mg/ml at 25° C), methanol, and chloroform.
저장 :
Store at -20° C
비등점 :
~565.0° C at 760 mmHg (Predicted)
밀도 :
~1.1 g/cm3 (Predicted)
굴절률 :
n20D 1.55 (Predicted)
Optical Activity :
α22D +48 in methanol
IC50 :
HCT-116: IC50 = 0.01 nM (human); PBMC: IC50 = 0.03 nM (human); VDR: IC50 = 0.7 nM (human); T47D: IC50 = 1.3 nM (human); RWLeu4: IC50 = 6 nM (human)
Ki 데이타 :
Vitamin D receptor: Ki= 0.03 nM (Gallus gallus); Vitamin D receptor: Ki= 0.05 nM (rat); HL-60: Ki= 2 nM (human)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
FZ4645000
PubChem CID :
Merck Index :
14: 1644
MDL Number :
MFCD00867079
EC Number :
250-963-8
Beilstein Registry :
7559394
SMILES :

SDS(MSDS)다운로드

분석증명서

PDF문서를 열람,
프린트와 코멘트를 작성하려면 Adobe Acrobat Reader가 필요합니다.

1α,25-Dihydroxyvitamin D3 (CAS 32222-06-3)  논문정보

다른 사용자의 1α,25-Dihydroxyvitamin D3 (CAS 32222-06-3)사용법보기. 클릭하여 PubMed entry보기 .

인용 1 to 10 of 29 합계

PMID: 33680716 | Ferrotoxicity and Its Amelioration by Calcitriol in Cultured Renal Cells. | Annamalai, C. et al. 2021. Anal Cell Pathol (Amst). 2021: 6634429.

PMID: 26774453 | Cellular analysis of the histamine H4 receptor in human myeloid cells. | Capelo, R. et al. 2016. Biochem. Pharmacol. 103: 74-84.

인용 1 to 10 of 29 합계
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 97ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 8ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;