p53R2 Inhibitors

Common p53R2 Inhibitors include, but are not limited to 2'-Deoxy-2',2'-difluorocytidine CAS 95058-81-4, Hydroxyurea CAS 127-07-1, Cisplatin CAS 15663-27-1, Doxorubicin CAS 23214-92-8 and Fluorouracil CAS 51-21-8.

p53R2 inhibitors pertain to a chemical class that specifically targets the p53-inducible ribonucleotide reductase small subunit 2 (p53R2) protein. This protein is involved in DNA synthesis and repair processes within the cell, particularly during times of DNA damage and stress. p53R2 is regulated by the tumor suppressor protein p53, which is a crucial factor in maintaining genomic integrity and stopping the propagation of damaged DNA.

By inhibiting p53R2, these compounds disrupt DNA replication and repair mechanisms, which could influence the cell's ability to accurately replicate its genetic material and respond to various forms of DNA damage. Inhibition of p53R2 may trigger specific cellular responses, leading to alterations in cell cycle progression and survival mechanisms. Such inhibitors provide a valuable tool for researchers to elucidate the role of p53R2 in DNA maintenance, replication, and repair pathways, aiding in a deeper understanding of cellular processes related to genomic stability and contributing to the development of strategies for addressing DNA-related diseases.