p53 Activators
Items 21 to 26 of 26 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
COTI-2 | 1039455-84-9 | sc-507291 | 25 mg | $310.00 | ||
COTI-2 reactivates mutant p53 by disrupting its interaction with heat shock proteins. | ||||||
p53 Activator II, Cell-Permeable | sc-364561 | 500 µg | $305.00 | |||
p53 Activator II is a cell-permeable compound that enhances the stability and activity of the p53 tumor suppressor protein. It engages in specific molecular interactions that promote p53's binding to DNA, facilitating the transcription of target genes involved in cell cycle regulation and apoptosis. This activator also influences post-translational modifications of p53, enhancing its response to cellular stress. Its unique ability to traverse cellular membranes allows for effective modulation of p53 pathways, impacting cellular homeostasis. | ||||||
2-Vinyl-4-quinazolinol | 91634-12-7 | sc-308709 | 250 mg | $143.00 | ||
2-Vinyl-4-quinazolinol is a small molecule that activates p53 by an undisclosed mechanism. | ||||||
p53 Activator, Cell-Permeable | sc-364562 | 500 µg | $222.00 | |||
p53 Activator, Cell-Permeable is a small molecule designed to modulate the p53 signaling pathway by stabilizing the p53 protein and promoting its oligomerization. This compound enhances p53's affinity for regulatory elements in the genome, leading to increased transcriptional activation of genes that govern cellular stress responses. Its ability to penetrate cell membranes allows for rapid intracellular action, influencing downstream signaling cascades and cellular fate decisions. | ||||||
NSC-207895 | 58131-57-0 | sc-364550 sc-364550A | 5 mg 10 mg | $347.00 $653.00 | ||
NSC-207895 is a potent small molecule that selectively enhances the stability of the p53 protein, facilitating its interaction with DNA. By promoting the formation of p53 tetramers, it effectively increases the protein's binding affinity to specific promoter regions, thereby amplifying the transcription of target genes involved in apoptosis and cell cycle regulation. Its unique structural features enable efficient cellular uptake, allowing for swift modulation of p53-mediated pathways. | ||||||
RG-7112 | 939981-39-2 | sc-507292 | 10 mg | $520.00 | ||
RG7112 is a small molecule that inhibits the interaction between MDM2 and p53. MDM2 normally binds to p53 and marks it for degradation. By inhibiting this interaction, RG7112 prevents MDM2 from tagging p53 for degradation, leading to the stabilization and activation of p53, which can then carry out its tumor-suppressing functions. | ||||||