OTTMUSG00000019145 Activators
Histidine-rich glycoprotein (HRG) is a multifunctional plasma protein that plays a critical role in various physiological processes, including the regulation of angiogenesis, coagulation, immune responses, and cell adhesion. HRG's structure allows it to interact with a wide range of ligands, including heparin, fibrinogen, and phospholipids, making it a key player in the modulation of these processes. The activation and function of HRG are influenced by these interactions, which can alter its conformation and consequently its activity.
The mechanisms of HRG activation and function are complex due to its ability to bind multiple ligands and its involvement in diverse biochemical pathways. Its activity can be modulated by changes in the concentrations of its binding partners or by alterations in the physiological or pathological state of the organism. For example, in the context of coagulation, HRG can bind to fibrinogen and heparin, balancing clot formation and breakdown. In angiogenesis, HRG's interaction with specific growth factors and inhibitors can either promote or inhibit new blood vessel formation. Understanding the exact mechanisms of HRG activation and its subsequent effects on various physiological processes remains a critical area of research.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions are known to stabilize protein structures. Zinc supplementation could potentially enhance the stability and function of HRG, possibly influencing its binding affinities and interactions. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Heparin, a known binder to HRG, might modulate its activity. The interaction between heparin and HRG can influence various physiological processes, such as coagulation and immune response. | ||||||
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $135.00 | ||
L-α-Lecithin, a key phospholipid, might interact with HRG, potentially affecting its role in cell signaling and apoptosis, as HRG is known to bind to phospholipids. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium ions are crucial in blood coagulation. HRG, being involved in coagulation, might be influenced by calcium levels, potentially affecting its functional state and interactions. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper ions can interact with proteins and modify their activity. Copper might influence HRG's structural conformation or its interaction with other molecules. | ||||||
Fibrinogen fraction 1 | 9001-32-5 | sc-473503 sc-473503A sc-473503B | 1 g 5 g 25 g | $135.00 $562.00 $2654.00 | ||
Fibrinogen, a key player in clot formation, might interact with HRG, affecting its role in coagulation and fibrinolysis, processes in which HRG is known to be involved. | ||||||
Collagen IV | sc-29010 | 1 mg | $224.00 | 11 | ||
Collagen, as a major component of the extracellular matrix, might interact with HRG, influencing its role in cell adhesion and migration. | ||||||
Adenosine-5′-Diphosphate, free acid | 58-64-0 | sc-291846 sc-291846A sc-291846B sc-291846C sc-291846D sc-291846E | 100 mg 500 mg 1 g 10 g 100 g 500 g | $79.00 $184.00 $348.00 $942.00 $4688.00 $9370.00 | 1 | |
ADP, involved in platelet aggregation, might interact with HRG, affecting its role in modulating platelet function and coagulation. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
Thrombin, a key enzyme in coagulation, might modulate HRG activity, as HRG is known to interact with coagulation factors. | ||||||
L-Cysteine | 52-90-4 | sc-286072 sc-286072A sc-286072B sc-286072C sc-286072D | 25 g 100 g 500 g 5 kg 10 kg | $51.00 $112.00 $449.00 $1151.00 $2178.00 | 1 | |
Cysteine could influence HRG's conformation and function due to its role in protein structure through disulfide bonds. | ||||||