OTTMUSG00000016780 Activators
Histone cluster 2 family member, a protein closely associated with chromatin structure, plays a critical role in regulating gene expression by influencing the accessibility of DNA to transcription factors and the transcriptional machinery. This protein is pivotal in modulating the epigenetic landscape through histone modifications, ultimately affecting gene transcription. It is noteworthy that the activation of histone cluster 2 family member is tightly linked to specific chemical compounds that can influence its function. The activation of histone cluster 2 family member is primarily achieved through the modulation of chromatin structure, specifically through histone acetylation. Chemicals such as Trichostatin A, Sodium Butyrate, and Valproic Acid function as histone deacetylase (HDAC) inhibitors, leading to increased histone acetylation. This histone modification results in a more accessible chromatin configuration, facilitating the binding of transcription factors and promoting the transcriptional activation of histone cluster 2 family member.
Additionally, compounds like Curcumin and Resveratrol activate histone cluster 2 family member indirectly by influencing specific signaling pathways. Curcumin activates the protein through the NF-κB pathway, promoting the transcription of NF-κB-responsive genes, including histone cluster 2 family member. Resveratrol, on the other hand, modulates the SIRT1 pathway by inhibiting SIRT1 deacetylase activity, leading to increased histone acetylation and gene transcription. Furthermore, epigenetic regulation of histone cluster 2 family member is facilitated by DNA methylation inhibitors like Epigallocatechin Gallate and 5-Aza-2'-deoxycytidine. These compounds demethylate the DNA at the gene promoter region, promoting an active chromatin state that favors gene transcription and protein expression. Indirect activation through signaling pathways is also observed with chemicals like SB203580 and PD98059, which affect the p38 MAPK and MEK/ERK pathways, respectively. These pathways ultimately influence the transcriptional activation of histone cluster 2 family member by altering gene expression patterns. In summary, the activation of histone cluster 2 family member is a complex process involving the modulation of chromatin structure, DNA methylation, and specific signaling pathways. Understanding the interplay of these mechanisms is crucial for unraveling the regulatory network of this essential protein in the context of epigenetic regulation and gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a potent inhibitor of histone deacetylases (HDACs), leading to histone hyperacetylation. This modification enhances chromatin accessibility and promotes the transcriptional activation of histone cluster 2 family member by allowing greater access to the gene promoter regions. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium butyrate acts as a histone deacetylase (HDAC) inhibitor, similar to Trichostatin A. It enhances histone acetylation, promoting a more permissive chromatin structure that favors gene activation of histone cluster 2 family member by facilitating transcription factor binding. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid functions as an HDAC inhibitor, increasing histone acetylation levels. This modification positively influences the chromatin structure at the histone cluster 2 family member gene locus, leading to enhanced gene expression through an open chromatin configuration. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been reported to activate histone cluster 2 family member indirectly through the NF-κB pathway. It promotes the transcription of NF-κB-responsive genes, including histone cluster 2 family member, which is positively influenced by NF-κB binding to its promoter region. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates histone cluster 2 family member by modulating the SIRT1 pathway. SIRT1 deacetylase activity is inhibited by resveratrol, resulting in increased histone acetylation and, consequently, the promotion of histone cluster 2 family member gene transcription. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) functions as an activator by inhibiting DNA methyltransferases (DNMTs). By reducing DNA methylation at the promoter region of histone cluster 2 family member, EGCG facilitates increased gene transcription and protein expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2'-deoxycytidine, a demethylating agent, can activate histone cluster 2 family member by inhibiting DNA methyltransferases (DNMTs). It leads to DNA demethylation at the gene promoter, promoting a more active state that favors gene transcription and protein expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 activates histone cluster 2 family member indirectly through the p38 MAPK pathway. Activation of p38 MAPK results in downstream signaling events that lead to transcriptional activation of target genes, including histone cluster 2 family member. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 activates histone cluster 2 family member indirectly by inhibiting the MEK/ERK pathway. Inhibition of this pathway leads to altered gene expression patterns, including increased transcription of histone cluster 2 family member. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
Sodium arsenite activates histone cluster 2 family member through oxidative stress. It induces the generation of reactive oxygen species (ROS), which can activate redox-sensitive transcription factors, ultimately resulting in the upregulation of histone cluster 2 family member. | ||||||