OTTMUSG00000013284 Inhibitors
The inhibition of the protein Gm13667 by the listed chemicals is based on general principles of protein biochemistry and inhibition. These chemicals have been chosen for their ability to interact with and inhibit proteins with specific structural or functional characteristics that Gm13667 might possess. For instance, Phenylmethylsulfonyl fluoride and AEBSF target serine residues in active sites, suggesting that if Gm13667 has serine protease-like activity, these inhibitors would be effective. Similarly, Iodoacetamide and Allicin target cysteine residues, and their effectiveness would depend on the presence of such residues in Gm13667's active site.
Chelating agents like EDTA and O-Phenanthroline have been included due to their ability to inhibit metalloproteins by removing essential metal cofactors, which would be effective if Gm13667 is a metalloprotein. Protease inhibitors like E-64, Pepstatin A, Leupeptin, Bestatin, MG-132, and Lactacystin have been selected based on their specific inhibitory action on different classes of proteases. If Gm13667 falls into one of these classes, such as serine protease, cysteine protease, aspartic protease, aminopeptidase, or proteasome, these inhibitors would impede its function. This approach of selecting chemical inhibitors is based on the potential characteristics of Gm13667, inferred from common protein functionalities. The actual inhibition of Gm13667 by these chemicals would require experimental validation, as these are theoretical selections based on known protein-inhibitor interactions.
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Items 1 to 10 of 20 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phenylmethylsulfonyl Fluoride | 329-98-6 | sc-3597 sc-3597A | 1 g 100 g | $50.00 $697.00 | 92 | |
Phenylmethylsulfonyl fluoride is a serine protease inhibitor that could inhibit Gm13667 by reacting with the serine residue in its active site, assuming Gm13667 has protease-like activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Acetate inhibits olfactory receptor 1506-like isoform X1 by altering the receptor′s conformation through its interaction with the zinc-binding sites present on the receptor. This interaction prevents the receptor from adopting the active conformation necessary for odorant binding and signal transduction. | ||||||
α-Iodoacetamide | 144-48-9 | sc-203320 | 25 g | $255.00 | 1 | |
α-Iodoacetamide can inhibit proteins with cysteine residues in their active sites. If Gm13667 has such cysteine residues, iodoacetamide would form covalent adducts with them, inhibiting the protein's function. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper(II) sulfate can inhibit olfactory receptor 1506-like isoform X1 by binding to specific sites on the receptor, which are normally involved in the binding of odorant molecules. This binding disrupts the normal function of the receptor, preventing it from effectively sensing and responding to odorant molecules. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
E-64 irreversibly inhibits cysteine proteases. If Gm13667 has a similar mechanism, E-64 could covalently bind to its active site cysteine, inhibiting its activity. | ||||||
Silver nitrate | 7761-88-8 | sc-203378 sc-203378A sc-203378B | 25 g 100 g 500 g | $114.00 $378.00 $1081.00 | 1 | |
Silver Nitrate acts as an inhibitor of olfactory receptor 1506-like isoform X1 by interacting with thiol groups present in the receptor. This interaction leads to a change in the receptor structure, thereby inhibiting its ability to bind to odorant molecules and initiate signal transduction. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamaldehyde inhibits olfactory receptor 1506-like isoform X1 by competitively binding to the receptor′s odorant binding site, thus preventing the binding of natural odorant molecules. This competitive inhibition results in a decreased activation of the receptor′s signal transduction pathway. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
Menthol inhibits olfactory receptor 1506-like isoform X1 by binding to a site distinct from the odorant binding site, causing a conformational change in the receptor. This change reduces the receptor′s affinity for its natural odorant ligands, thus inhibiting its functional response to these molecules. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
Leupeptin inhibits serine and cysteine proteases. If Gm13667 is of this type, leupeptin would bind to its active site and inhibit its function. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol directly inhibits olfactory receptor 1506-like isoform X1 by interacting with specific amino acid residues in the receptor′s ligand-binding domain. This interaction alters the receptor′s conformation, hindering its ability to bind to odorant molecules and subsequently inhibiting signal transduction. | ||||||