OST4 Activators
OST4, or Oligosaccharyltransferase 4, is a protein encoded by the OST4 gene in humans. This protein is part of the oligosaccharyltransferase (OST) complex, a group of proteins that play a crucial role in the process of protein glycosylation.Protein glycosylation is a post-translational modification, where complex sugar molecules (glycans) are attached to proteins. This modification can dramatically affect a protein's function, stability, and location within the cell.
The OST complex, including OST4, is located in the membrane of the endoplasmic reticulum (ER), an organelle involved in protein synthesis and processing. The primary role of the OST complex is to transfer a pre-assembled oligosaccharide group from a lipid carrier to an asparagine residue on a nascent protein. This process is known as N-linked glycosylation.As a component of the OST complex, OST4 is critical for its stability and function. It's thought to play a role in maintaining the structure of the complex, and its absence can disrupt the function of the entire OST complex.Alterations in the OST4 gene or the OST4 protein could potentially disrupt the function of the OST complex and thereby affect protein glycosylation. This, in turn, could lead to the production of improperly glycosylated proteins, which could contribute to a variety of diseases, including congenital disorders of glycosylation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin induces ER stress, which can impact protein glycosylation and potentially affect OST4 activity. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
4-PBA is a chemical chaperone that alleviates ER stress, potentially influencing OST4's role in glycosylation. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts Golgi apparatus dynamics, which might indirectly affect OST4 and N-linked glycosylation processes. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132, a proteasome inhibitor, can affect protein turnover and ER-associated degradation, potentially impacting OST4 function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased cAMP levels, which may indirectly influence OST4 in the ER. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a compound in turmeric, affects multiple signaling pathways and might have an indirect impact on OST4. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, affects various cellular processes including protein synthesis, potentially influencing OST4. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Carbonate, studied in the research of bipolar disorder, can affect various cellular processes, potentially impacting OST4. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose can mimic glucose deprivation, potentially affecting N-linked glycosylation and OST4 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a catechin found in green tea, can influence various signaling pathways, potentially modulating OST4 activity. | ||||||