OSTα Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin inhibits OSTα by binding directly to the protein, disrupting its normal function in bile acid transport. This interaction leads to a decrease in OSTα-mediated bile acid efflux, effectively inhibiting the protein's activity in cellular bile acid homeostasis. | ||||||
Ursodeoxycholic acid | 128-13-2 | sc-204935 sc-204935A | 1 g 5 g | $52.00 $131.00 | 4 | |
Ursodeoxycholic acid inhibits OSTα by altering the bile acid pool composition, which indirectly impacts the protein's activity. This change in bile acid composition can lead to reduced stimulation of OSTα, thereby inhibiting its function in bile acid transport across cell membranes. | ||||||
(E)-Guggulsterone | 39025-24-6 | sc-294461 sc-294461A | 5 mg 10 mg | $510.00 $902.00 | 1 | |
(E)-Guggulsterone inhibits OSTα by competitively binding to the protein, preventing its interaction with natural bile acid substrates. This inhibition reduces the efficiency of bile acid transport, directly impacting OSTα's role in maintaining bile acid homeostasis. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A inhibits OSTα by interfering with its expression and/or membrane localization, significantly reducing the protein's ability to transport bile acids. This effect directly diminishes OSTα's function in the regulation of bile acid homeostasis within cells. | ||||||
Dehydroandrographoline | 134418-28-3 | sc-280669 | 25 mg | $220.00 | ||
Dehydroandrographolide inhibits OSTα by modulating signaling pathways that downregulate the protein's expression or activity. This leads to a decrease in OSTα function, impacting its role in bile acid efflux and overall cellular bile acid regulation. | ||||||
Geniposide | 24512-63-8 | sc-279180 sc-279180A | 10 mg 25 mg | $80.00 $90.00 | ||
Geniposide is a natural compound found in several plants, including Gardenia jasminoides. It has been reported to inhibit OSTα, potentially affecting bile acid and sterol metabolism. | ||||||