Date published: 2025-12-24

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OR6V1 Inhibitors

OR6V1 inhibitors are a category of chemical compounds that interact with the olfactory receptor OR6V1. The OR6V1 receptor is one of the numerous receptors found in the olfactory system, which is responsible for the sense of smell. Olfactory receptors are a subset of G protein-coupled receptors (GPCRs), which are a large and diverse group of membrane receptors that respond to a variety of external signals. These receptors are characterized by their seven transmembrane domains, and they initiate a chemical response when an odorant molecule binds to them. The OR6V1 receptor, like other olfactory receptors, is expressed on the olfactory sensory neurons within the nasal cavity and is involved in the detection of specific molecules that contribute to the perception of odors. Inhibitors of OR6V1 are compounds designed to bind to this receptor and prevent it from activating. This inhibition can be competitive or non-competitive. Competitive inhibitors typically resemble the structure of the natural odorant ligand and compete for binding to the active site of the receptor. Non-competitive inhibitors, on the other hand, bind to a different part of the receptor, causing a change in its shape or function, which indirectly prevents the binding of the odorant molecule. The interaction between OR6V1 inhibitors and the OR6V1 receptor is a subject of interest in the field of biochemistry and molecular biology, as it helps to elucidate the complex mechanisms of smell. The study of these inhibitors provides insight into how olfactory receptors are activated and deactivated, which is crucial for understanding the fundamental processes of olfaction at the molecular level.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Quinine

130-95-0sc-212616
sc-212616A
sc-212616B
sc-212616C
sc-212616D
1 g
5 g
10 g
25 g
50 g
$77.00
$102.00
$163.00
$347.00
$561.00
1
(0)

Quinine is an alkaloid that can interfere with G-protein-coupled receptor (GPCR) signaling, potentially leading to the inhibition of OR6V1 by disrupting the normal GPCR signaling cascade that OR6V1 participates in.

Capsaicin

404-86-4sc-3577
sc-3577C
sc-3577D
sc-3577A
50 mg
250 mg
500 mg
1 g
$94.00
$173.00
$255.00
$423.00
26
(1)

Capsaicin, the active component in chili peppers, can desensitize sensory neurons and may reduce OR6V1 activity by modulating the sensory pathways that OR6V1 is involved in.

Ibotenic acid

2552-55-8sc-200449
sc-200449A
1 mg
5 mg
$118.00
$412.00
1
(1)

Ibotenic acid is a neurotoxic compound that can act as an agonist for glutamate receptors, possibly leading to the inhibition of OR6V1 through downstream effects on neural pathways that intersect with OR6V1's signaling.

Copper(II) sulfate

7758-98-7sc-211133
sc-211133A
sc-211133B
100 g
500 g
1 kg
$45.00
$120.00
$185.00
3
(1)

Copper sulfate can bind to and block various receptor sites, potentially resulting in the inhibition of OR6V1 activity by altering the receptor's conformation or blocking ligand access.

(−)-Menthol

2216-51-5sc-202705
sc-202705A
1 g
50 g
$20.00
$40.00
2
(1)

Menthol affects sensory receptors and could inhibit OR6V1 by modulating sensory transduction pathways that OR6V1 is involved with, potentially altering perception and receptor response.

Lidocaine

137-58-6sc-204056
sc-204056A
50 mg
1 g
$50.00
$128.00
(0)

Lidocaine is a local anesthetic that can block sodium channels, which may indirectly lead to the inhibition of OR6V1 by dampening the excitability of neurons expressing the receptor.

Chloroquine

54-05-7sc-507304
250 mg
$68.00
2
(0)

Chloroquine is a medication known to alter the glycosylation of proteins, which could inhibit OR6V1 by affecting its proper folding and surface expression on sensory neurons.

Verapamil

52-53-9sc-507373
1 g
$367.00
(0)

Verapamil is a calcium channel blocker that can reduce the activity of calcium-dependent processes, potentially leading to an indirect inhibition of OR6V1 through the modulation of intracellular signaling pathways.

Hexamethonium bromide

55-97-0sc-205712
sc-205712A
10 g
25 g
$45.00
$63.00
(0)

Hexamethonium is a nicotinic acetylcholine receptor antagonist that might inhibit OR6V1 indirectly by altering parasympathetic signaling pathways that could intersect with OR6V1's function.