Date published: 2025-11-1

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OR5M1 Inhibitors

Chemical inhibitors of OR5M1 can modulate the receptor's activity through various binding interactions that either directly or allosterically affect its conformation and signaling capabilities. Benzaldehyde, for instance, can inhibit OR5M1 by occupying the odorant binding site, which is the same site where the natural ligand would typically bind. This action prevents the natural ligand from interacting with OR5M1, directly inhibiting the receptor's function. Similarly, Phenylethyl alcohol operates through competitive inhibition at the active site, thus blocking the natural ligand's access and inhibiting the signaling process of OR5M1. Isoamyl acetate and Citral also can employ a competitive mechanism by binding to the odorant binding site, effectively preventing the activation of the receptor by its endogenous activating ligands. On the other hand, some chemical inhibitors can influence OR5M1 function by binding to sites other than the primary odorant binding site. Methyl jasmonate, for example, can bind to an allosteric site on OR5M1, which can induce conformational changes that reduce the receptor's ability to respond to its natural ligands. Eugenol and Methimazole can similarly inhibit OR5M1 by inducing conformational changes, either by stabilizing the receptor in an inactive conformation or by binding to the active site or adjacent allosteric sites, respectively. Cinnamaldehyde, Anethole, and Carvone can also interact with OR5M1 to promote a receptor conformation that does not favor activation, thereby inhibiting the receptor's signaling. Lastly, Thymol and Menthol can inhibit OR5M1 by binding to the active site or regions important for receptor activation, preventing the necessary conformational changes required for the receptor to signal effectively.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

(±)-Methyl Jasmonate

39924-52-2sc-205386
sc-205386A
sc-205386B
sc-205386C
sc-205386D
sc-205386E
sc-205386F
1 g
5 g
10 g
50 g
100 g
500 g
1 kg
$35.00
$103.00
$200.00
$873.00
$1638.00
$6942.00
$12246.00
(1)

Methyl jasmonate can inhibit OR5M1 by binding to an allosteric site on the receptor, which can induce a conformational change that results in a decrease in the receptor's ability to respond to its activating ligands, thereby inhibiting its function.

2-Phenylethanol

60-12-8sc-238198
250 ml
$68.00
(0)

Phenylethyl alcohol can inhibit OR5M1 by competitively binding to the active site, preventing activation by the receptor's natural ligand and thus inhibiting the receptor's signaling capabilities.

Eugenol

97-53-0sc-203043
sc-203043A
sc-203043B
1 g
100 g
500 g
$31.00
$61.00
$214.00
2
(1)

Eugenol can inhibit OR5M1 by stabilizing the receptor in an inactive conformation upon binding, which prevents activation by endogenous activating ligands, inhibiting signal transduction.

Methimazole

60-56-0sc-205747
sc-205747A
10 g
25 g
$69.00
$110.00
4
(0)

Methimazole can inhibit OR5M1 by binding to the active site or adjacent allosteric sites, which may result in a conformational change that reduces the receptor's activity and inhibits its signaling function.

Cinnamic Aldehyde

104-55-2sc-294033
sc-294033A
100 g
500 g
$102.00
$224.00
(0)

Cinnamaldehyde can inhibit OR5M1 by binding to the ligand-binding domain, which may alter the receptor's conformation in a way that reduces its ability to be activated by its natural ligands, thus inhibiting its function.

Anethole

104-46-1sc-481571A
sc-481571
10 g
100 g
$565.00
$310.00
(0)

Anethole can inhibit OR5M1 by interacting with specific regions on the receptor that are necessary for activation and, upon binding, prevents the receptor from achieving an active conformation, thereby inhibiting OR5M1 activity.

Thymol

89-83-8sc-215984
sc-215984A
100 g
500 g
$97.00
$193.00
3
(0)

Thymol can inhibit OR5M1 by binding to the receptor's active site, which may hinder the receptor's conformational change required for activation, therefore inhibiting its signaling pathway.

Isopentyl acetate

123-92-2sc-250190
sc-250190A
100 ml
500 ml
$105.00
$221.00
(0)

Isoamyl acetate can inhibit OR5M1 by competitively binding to the active site, which directly prevents the activation by natural ligands and inhibits the receptor's ability to initiate a cellular response.

Citral

5392-40-5sc-252620
1 kg
$212.00
(1)

Citral can inhibit OR5M1 by competitively inhibiting at the odorant binding site, which may lead to a decrease in receptor activity by preventing the binding and activation by natural activating ligands.

(+)-Carvone

2244-16-8sc-239480
sc-239480A
5 ml
25 ml
$32.00
$82.00
2
(1)

Carvone can inhibit OR5M1 by binding to the receptor's active site and promoting a conformation that does not favor activation, effectively inhibiting the receptor's ability to respond to ligand binding.