OR5AN1 Activators
OR5AN1 can engage different intracellular signaling pathways that lead to its activation. Forskolin, for instance, directly activates adenylyl cyclase, which increases cyclic AMP (cAMP) levels within the cell. cAMP is a crucial second messenger that can activate cAMP-dependent pathways, including protein kinase A (PKA), which, in turn, can activate OR5AN1. Similarly, Isoproterenol, a synthetic catecholamine, and Adrenaline, a naturally occurring hormone, bind to beta-adrenergic receptors. These receptors are part of the G protein-coupled receptor (GPCR) family, like OR5AN1, and their activation leads to an increase in cAMP production through the stimulation of Gs proteins. The increase in cAMP levels can lead to the activation of OR5AN1 through PKA signaling pathways. Glucagon acts in a corresponding manner by binding to its specific GPCR, again resulting in elevated cAMP levels and subsequent activation of OR5AN1.
Other chemical activators operate through different mechanisms but also converge on the pathways that can activate OR5AN1. For example, Prostaglandin E2 (PGE2) binds to its GPCR and activates the Gs protein, which also culminates in an increase in cAMP and activation of OR5AN1. Histamine and Serotonin, by binding to their respective GPCRs, can modulate intracellular Ca2+ levels or cAMP levels, both of which are capable of leading to the activation of OR5AN1 through G protein-coupled signaling pathways. Dopamine and Noradrenaline, by interacting with their GPCRs, can lead to increased cAMP levels or variations in Ca2+ signaling, which are pathways that can activate OR5AN1. Acetylcholine can bind to muscarinic acetylcholine receptors, influencing cAMP or Ca2+ levels, which may activate OR5AN1 depending on the specific receptor subtype engaged. Lastly, Angiotensin II and Oxytocin can bind to their respective GPCRs, affecting signaling pathways that include alterations in Ca2+ levels, ultimately leading to the activation of OR5AN1 through G protein-coupled receptor pathways that are responsive to intracellular Ca2+ dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates beta-adrenergic receptors, which are G protein-coupled receptors like OR5AN1. The activation of these receptors can stimulate the production of cAMP, potentially leading to the downstream activation of OR5AN1 via protein kinase A (PKA) signaling. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) binds to its G protein-coupled receptors, leading to the activation of the Gs protein and subsequent increase in cAMP. This process can activate OR5AN1 by enhancing the cAMP signaling pathway, which is commonly engaged by G protein-coupled receptors. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine can activate G protein-coupled histamine receptors, which can lead to the modulation of intracellular Ca2+ levels. The change in intracellular calcium can influence the activation of OR5AN1 through G protein-coupled pathways that are sensitive to Ca2+ levels. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine binds to its G protein-coupled receptors, leading to diverse intracellular effects depending on the receptor subtype activated. This can result in increased cAMP levels or alterations in Ca2+ signaling, which can activate OR5AN1 through related signaling cascades. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Adrenaline engages with adrenergic receptors, triggering G protein-coupled receptor signaling that increases cAMP levels. This surge in cAMP can activate OR5AN1 by promoting cAMP-dependent signaling pathways. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $530.00 | 3 | |
Serotonin interacts with various serotonin receptors, many of which are G protein-coupled. The activation of these receptors can lead to alterations in cAMP or Ca2+ levels, which could activate OR5AN1 through these second messenger pathways. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Noradrenaline activates alpha and beta-adrenergic receptors that influence G protein-coupled signaling pathways, modifying cAMP levels, which can lead to OR5AN1 activation by stimulating the associated signaling cascades. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II binds to its G protein-coupled receptors, affecting numerous signaling pathways, including phospholipase C, which can alter Ca2+ dynamics. These changes can activate OR5AN1 through G protein-coupled receptor pathways sensitive to Ca2+ signaling. | ||||||
Oxytocin acetate salt | 50-56-6 | sc-279938 sc-279938A sc-279938B sc-279938C sc-279938D sc-279938E | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $60.00 $180.00 $337.00 $663.00 $969.00 $1836.00 | 4 | |
Oxytocin binds to G protein-coupled receptors that can influence intracellular Ca2+ levels. The alteration in Ca2+ signaling could activate OR5AN1 through G protein-coupled receptor signaling pathways that are responsive to changes in intracellular Ca2+. | ||||||