Date published: 2025-10-11

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OR5AK2 Activators

OR5AK2 include a variety of compounds commonly found in essential oils and fragrances. Citral, a major component in lemongrass oil, engages OR5AK2 by docking to its ligand-binding site, triggering a series of intracellular reactions starting with a signal transduction cascade. Similarly, eugenol, which is found in clove oil, targets the receptor's binding domain, activating OR5AK2 and promoting a cellular response through associated G-proteins. Geraniol, another floral scent from rose oil and citronella, interacts with the sensory domain of OR5AK2, initiating G-protein-mediated signaling pathways. Methyl salicylate, known for its minty scent reminiscent of wintergreen, also participates in the activation of OR5AK2 by fitting snugly into the receptor's pocket, prompting a conformational change that propagates the signal through G-protein coupling.

OR5AK2, benzyl acetate, with its sweet floral aroma, binds to the receptor's active site, ensuing G-protein activation and the cascade of intracellular signaling. Isoamyl acetate, with its distinctive banana-like scent, engages OR5AK2 at its olfactory receptor site, leading to the activation of downstream signaling events. Limonene, found in citrus peels, and linalool, present in lavender and coriander, both activate OR5AK2 by binding to its ligand-binding domain, causing a change in receptor structure that triggers G-protein signaling. Similarly, alpha-ionone and beta-ionone, which emit violet-like scents, activate OR5AK2 by interacting with the active site of the receptor, inducing a series of signaling events inside the cell. Hexyl acetate adds to this list with its fruity fragrance, activating OR5AK2 by binding to the receptor's ligand-binding site, while alpha-terpineol, which offers a lilac scent, also activates the receptor, signaling through G-protein activation and subsequent intracellular pathways.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Citral

5392-40-5sc-252620
1 kg
$212.00
(1)

Citral is a component of lemongrass oil and activates olfactory receptors, which could include OR5AK2. By binding directly to the ligand-binding site of this olfactory receptor, citral triggers a signal transduction cascade leading to activation.

Eugenol

97-53-0sc-203043
sc-203043A
sc-203043B
1 g
100 g
500 g
$31.00
$61.00
$214.00
2
(1)

Eugenol, found in clove oil, is known to activate olfactory receptors. It can activate OR5AK2 by interacting with the receptor's specific binding domain, initiating a cellular response via associated G-proteins.

Geraniol

106-24-1sc-235242
sc-235242A
25 g
100 g
$44.00
$117.00
(0)

Geraniol, present in rose oil and citronella, is another olfactory receptor activator. It could activate OR5AK2 by binding to its sensory domain, promoting G-protein-mediated signaling pathways.

Methyl Salicylate

119-36-8sc-204802
sc-204802A
250 ml
500 ml
$46.00
$69.00
(1)

Methyl salicylate, a wintergreen scent compound, can activate OR5AK2 by binding to its receptor pocket, which would initiate a conformational change and signal transduction through G-protein coupling.

Benzyl acetate

140-11-4sc-252427
100 g
$29.00
1
(0)

Benzyl acetate, a floral scent compound, may activate OR5AK2 by binding to the olfactory receptor's active site, triggering G-protein activation and subsequent intracellular signaling cascades.

Isopentyl acetate

123-92-2sc-250190
sc-250190A
100 ml
500 ml
$105.00
$221.00
(0)

Isoamyl acetate, known for its banana-like scent, could activate OR5AK2 by binding to its olfactory receptor site, leading to activation of G-proteins and a series of downstream signaling events.

D-Limonene

5989-27-5sc-205283
sc-205283A
100 ml
500 ml
$82.00
$126.00
3
(1)

Limonene, a citrus scent compound, can activate OR5AK2 by specifically binding to its ligand-binding domain, causing a receptor conformational change that activates G-protein signaling.

Linalool

78-70-6sc-250250
sc-250250A
sc-250250B
5 g
100 g
500 g
$46.00
$71.00
$108.00
(0)

Linalool, a component of lavender and coriander, may activate OR5AK2 by specifically interacting with its receptor site, leading to the activation of G-proteins and subsequent signaling pathways.

α-Ionone

127-41-3sc-239157
100 g
$75.00
(0)

Alpha-ionone, which has a violet-like scent, could activate OR5AK2 by binding to the olfactory receptor and causing a conformational change, resulting in G-protein activation and signal transduction.

beta-Ionone

14901-07-6sc-291976
25 ml
$83.00
(0)

Beta-ionone, similar to alpha-ionone, may activate OR5AK2 by binding to the receptor's active site, leading to G-protein-mediated intracellular signaling events.