OR52D1 Activators
OR52D1 operate through various molecular mechanisms to initiate a cascade of intracellular signaling events that ultimately result in the activation of this odorant receptor. Isoamyl acetate, for example, binds to OR52D1, causing a conformational change that leads to the activation of G-proteins and a subsequent increase in intracellular calcium levels. Similarly, benzyl acetate interacts with OR52D1's ligand-binding domain, triggering cellular events that activate adenylate cyclase, leading to an increase in cyclic AMP (cAMP) and activation of protein kinase A (PKA), which phosphorylates cellular proteins and activates OR52D1. Ethyl vanillin and methyl salicylate also activate OR52D1 by binding to its ligand-binding site, resulting in G-protein activation and the subsequent cellular signaling events that lead to activation. Ethyl vanillin causes an increase in the production of inositol trisphosphate (IP3) and diacylglycerol (DAG), while methyl salicylate leads to a decrease in cAMP, both of which contribute to the activation of OR52D1.
2-phenylethanol, ethyl butyrate, citronellol, linalool, limonene, alpha-pinene, geraniol, and heptanoic acid are also able to activate OR52D1 through their specific interactions with the receptor. These chemicals initiate a signaling cascade by binding to OR52D1, leading to G-protein activation and subsequent activation of adenylate cyclase. This results in an increase in cAMP levels and the activation of PKA. The activation of PKA then leads to the phosphorylation of target proteins, which is a critical step in the activation of OR52D1. Each chemical, through its unique interaction with OR52D1, initiates a distinct pathway that converges on the common endpoint of receptor activation, demonstrating the versatility of OR52D1 in responding to a wide range of chemical signals.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isoamyl acetate is known to activate OR52D1 by binding to the odorant receptor and causing a conformational change that leads to signal transduction pathways involving G-proteins, ultimately causing an increase in intracellular calcium levels which is a measure of OR52D1 activation. | ||||||
Benzyl acetate | 140-11-4 | sc-252427 | 100 g | $29.00 | 1 | |
Benzyl acetate activates OR52D1 by interacting with the receptor's ligand-binding domain, triggering a cascade of cellular events that lead to the activation of adenylate cyclase, an increase in cAMP, and subsequent activation of protein kinase A (PKA), which can then phosphorylate various cellular proteins resulting in the functional activation of OR52D1. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
3-Ethoxy-4-hydroxybenzaldehyde activates OR52D1 by direct interaction with the receptor, causing a change in its structure that activates the associated G-protein, which in turn activates downstream effectors such as phospholipase C, resulting in the production of inositol trisphosphate (IP3) and diacylglycerol (DAG) and ultimately leading to the activation of OR52D1. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate activates OR52D1 by binding to its ligand-binding site, which leads to a conformational change in the receptor and activation of its associated G-protein. This activation then leads to downstream signaling events, including the activation of phosphodiesterases and a decrease in cAMP, which indirectly leads to the functional activation of OR52D1. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $68.00 | ||
2-Phenylethanol activates OR52D1 by molecular interaction with the receptor, which induces a G-protein-coupled receptor signaling cascade involving activation of adenylate cyclase and an increase in intracellular cAMP, which subsequently activates PKA and leads to cellular responses that include functional activation of OR52D1. | ||||||
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate is an activator of OR52D1 through its binding to the receptor, leading to G-protein activation, which subsequently activates adenylate cyclase, resulting in increased cAMP levels and activation of PKA, thereby causing a series of phosphorylation events that lead to the functional activation of OR52D1. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $31.00 $153.00 | ||
Citronellol activates OR52D1 by binding specifically to the receptor, initiating a G-protein signaling cascade that activates adenylate cyclase, increasing cAMP levels, which then activates PKA. The activation of PKA results in phosphorylation of target proteins and leads to the functional activation of OR52D1. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $46.00 $71.00 $108.00 | ||
Linalool activates OR52D1 by direct binding to the receptor, initiating a signaling cascade via G-protein activation, leading to an increase in cAMP and activation of PKA. This series of events results in phosphorylation and changes in cell function that culminate in the activation of OR52D1. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $82.00 $126.00 | 3 | |
Limonene activates OR52D1 by binding to its ligand-binding site, which triggers an intracellular G-protein-coupled signaling cascade that results in the activation of adenylate cyclase, an increase in cAMP levels, and the activation of PKA, leading to the functional activation of OR52D1. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $51.00 $113.00 | 2 | |
Alpha-Pinene is an activator of OR52D1 by its interaction with the receptor, causing a G-protein-coupled response that leads to activation of adenylate cyclase, an increase in cAMP levels, and subsequent activation of PKA, which then phosphorylates various substrates resulting in the activation of OR52D1. | ||||||