OR52A5 Activators
OR52A5 include a range of compounds that interact with the olfactory receptor, leading to its activation and subsequent signal transduction. Isopentenyl pyrophosphate, geranyl pyrophosphate, and farnesyl pyrophosphate are all prenyl pyrophosphates that serve as ligands for OR52A5. Upon binding, these molecules induce a conformational change in the receptor, which then activates the associated G-protein coupled receptor pathway, culminating in a range of cellular responses. Similarly, menthol, a compound known for its minty scent, activates OR52A5 by directly interacting with the receptor, thereby triggering a cascade of intracellular signaling events. Eucalyptol and citronellal, which are both known for their distinctive fragrances, activate OR52A5 by binding to the receptor and altering its conformation. This alteration promotes the initiation of the G-protein signaling cascade that is essential for the sensory perception of these odors.
Eugenol, limonene, alpha-pinene, and beta-caryophyllene interact with OR52A5 in a similar fashion. Eugenol, which is characterized by a clove scent, and limonene, associated with citrus odors, both fit into the ligand-binding domain of OR52A5. This interaction stimulates the olfactory signal transduction pathway, leading to the detection and perception of their respective scents. Alpha-pinene and beta-caryophyllene, known for pine and spicy-woody aromas, respectively, also activate OR52A5 through direct binding. This binding leads to G-protein activation and an olfactory response. Hexanal and benzaldehyde are two additional activators; hexanal contributes to the perception of green, grassy odors, while benzaldehyde is associated with an almond-like scent. Both chemicals achieve activation of OR52A5 by attaching to the receptor's binding site, prompting a conformational shift that triggers the olfactory signaling pathway, resulting in the neural processing of these distinct odors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Farnesyl pyrophosphate ammonium salt | 13058-04-3 | sc-200847 sc-200847A | 1 mg 5 mg | $478.00 $1977.00 | ||
Farnesyl pyrophosphate activates OR52A5 by direct binding, which in turn initiates G-protein signaling, leading to downstream effects such as ion channel opening and changes in cellular activity. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
Menthol activates OR52A5 by direct interaction with the receptor, causing a change in its structure that leads to activation of the olfactory signaling pathway and perception of mint odor. | ||||||
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $44.00 | 2 | |
Eucalyptol activates OR52A5 by binding to the olfactory receptor, which alters the receptor's conformation and initiates signal transduction mechanisms involving G-proteins, resulting in sensory perception. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal is an agonist of OR52A5, and its binding results in the activation of the receptor, which triggers the G-protein signaling cascade, ultimately leading to sensory neuron activation. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol activates OR52A5 by fitting into the receptor's ligand-binding domain, which stimulates the olfactory signal transduction pathway, leading to the perception of clove scent. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene engages and activates OR52A5 by binding to the olfactory receptor, prompting a G-protein mediated signal transduction, which contributes to the detection of citrus odors. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
Alpha-pinene activates OR52A5 by ligand binding, which induces a conformational change in the receptor, stimulating the associated G-proteins and leading to an olfactory response. | ||||||
(−)-trans-Caryophyllene | 87-44-5 | sc-251281 sc-251281A sc-251281B sc-251281C | 1 ml 5 ml 25 ml 1 L | $81.00 $160.00 $446.00 $2918.00 | 1 | |
Beta-caryophyllene activates OR52A5 through direct interaction with the receptor, initiating a signaling pathway involving G-protein activation, which contributes to the perception of spicy and woody aromas. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $27.00 | ||
Hexanal acts as an activator of OR52A5 by attaching to the receptor's binding site, leading to a conformational shift that triggers the G-protein coupled olfactory signaling pathway, resulting in the neural processing of green, grassy odors. | ||||||