OR51I1 Activators
OR51I1, such as isoamyl acetate, benzaldehyde, ethyl butyrate, eugenol, geranyl acetate, methyl salicylate, citronellal, heptanal, octanal, amyl acetate, and nonanal, initiate a complex biochemical process by binding to this olfactory receptor. Upon binding, these chemicals induce a conformational change in OR51I1, which is a classic hallmark of G-protein coupled receptor (GPCR) activation. This conformational shift facilitates the interaction of OR51I1 with the attached G-protein, promoting the exchange of GDP for GTP on the G-protein's alpha subunit. This exchange effectively activates the G-protein, setting off a cascade of intracellular events. One of the immediate consequences of this activation is the stimulation of adenylate cyclase, an enzyme responsible for the conversion of ATP to cyclic AMP (cAMP). As the concentration of cAMP rises within the cell, it acts as a second messenger, leading to the opening of cyclic nucleotide-gated ion channels.
The influx of ions through these channels, primarily calcium and sodium, results in the depolarization of the olfactory sensory neuron's membrane. This electrical change is the primary signal that an olfactory event has occurred. Each chemical mentioned has a unique molecular structure, which allows for specific interactions with OR51I1. For instance, eugenol and methyl salicylate bind to the hydrophobic pocket of the receptor, while citronellal and aliphatic aldehydes like heptanal, octanal, and nonanal interact with different specific sites on OR51I1. Despite the variance in binding interactions, the downstream effect remains largely consistent, leading to the generation of a neuronal signal. The signal is then propagated along the olfactory neurons to the brain, where it is interpreted as a distinct scent. This process is fundamental to the sense of smell and is universally employed by the above-mentioned chemical activators to engage the OR51I1 olfactory receptor.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl acetate is known to activate the OR51I1 protein by binding to the olfactory receptor and causing a conformational change that triggers signal transduction through the G-protein coupled receptor (GPCR) pathway. This leads to the activation of adenylate cyclase, an increase in cAMP levels, and the opening of ion channels, ultimately resulting in a neuronal response. | ||||||
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate serves as an agonist to OR51I1 by attaching to its binding site, which results in a structural alteration that activates the associated G-protein. The activated G-protein in turn activates adenylate cyclase, increasing intracellular cAMP levels and leading to the opening of ion channels that contribute to the depolarization of the olfactory sensory neuron. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol activates OR51I1 through the binding to the olfactory receptor, which triggers a GPCR-mediated signaling cascade. The activation of the G-protein, followed by an increase in cAMP, leads to the opening of ion channels and the propagation of an electrical signal in olfactory neurons, which is interpreted as a scent. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $41.00 | ||
Geranyl acetate activates OR51I1 by binding to the olfactory receptor's active site, leading to GPCR activation. The G-protein then activates adenylate cyclase, which catalyzes the conversion of ATP to cAMP, raising cAMP levels. This results in the opening of cyclic nucleotide-gated ion channels, allowing for the flow of ions and the initiation of an olfactory signal. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate activates OR51I1 by binding to the receptor’s hydrophobic pocket, leading to a conformational change that activates the G-protein. This activation results in the conversion of ATP to cAMP by adenylate cyclase, with a subsequent rise in cAMP levels causing the opening of ion channels, depolarization of the olfactory sensory neuron, and the initiation of a sensory signal. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal directly activates OR51I1 by binding to the receptor site, inducing a GPCR signal transduction. The activation of the G-protein leads to the activation of adenylate cyclase, which increases the levels of cAMP, facilitating the opening of ion channels, leading to neuronal signal transduction associated with olfaction. | ||||||
Heptaldehyde | 111-71-7 | sc-250089 sc-250089A | 2 ml 100 ml | $30.00 $59.00 | ||
Heptanal activates OR51I1 by binding to specific sites on the olfactory receptor, which are GPCRs, thus activating the receptor and its associated G-protein. The subsequent signal cascade involves the activation of adenylate cyclase, increased cAMP levels, and the opening of ion channels that translate into the olfactory sensory signal. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal activates OR51I1 by binding to the receptor, causing a change in its conformation and activating the G-protein. This activation triggers adenylate cyclase, which increases cAMP concentration, leading to the opening of ion channels that mediate the transduction of olfactory signals. | ||||||
Pentyl acetate | 628-63-7 | sc-215691 | 250 ml | $66.00 | ||
Pentyl acetate activates OR51I1 by interacting with the receptor binding site, thereby activating the GPCR pathway. The associated G-protein is activated, which stimulates adenylate cyclase to convert ATP to cAMP. The increase in cAMP levels leads to the activation of ion channels, causing a change in the membrane potential and initiating a signal in the olfactory sensory neurons. | ||||||
Nonanal | 124-19-6 | sc-257926 | 1 g | $67.00 | ||
Nonanal serves as an activator of OR51I1 by binding to the olfactory receptor, which results in conformational changes leading to GPCR activation. The activated G-protein promotes the conversion of ATP to cAMP by adenylate cyclase, leading toIt seems there has been a misunderstanding, as the content of the table you're requesting is not provided in your message. If you need information on a list of compounds, their CAS numbers, and descriptions of how they activate the OR51I1 olfactory receptor, please provide the list or specific details, and I will be happy to create a table with the information available up to my last training data in April 2023. | ||||||