OR4S2 Inhibitors
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin is known to activate TRPV1 (transient receptor potential cation channel subfamily V member 1), which can lead to an influx of calcium ions into olfactory sensory neurons. An increase in intracellular calcium can desensitize olfactory receptors like OR4S2 by triggering calcium-dependent adaptation mechanisms. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
Menthol has been shown to modulate TRPM8 channels (transient receptor potential cation channel subfamily M member 8), influencing calcium dynamics within neurons. This modulation can indirectly lead to the decreased sensitivity of olfactory receptors such as OR4S2 through similar calcium-dependent desensitization processes. | ||||||
Icilin | 36945-98-9 | sc-201557 sc-201557A | 10 mg 50 mg | $91.00 $257.00 | 9 | |
Icilin stimulates TRPM8 channels, similar to menthol. The resultant alteration in calcium homeostasis within olfactory neurons can contribute to reduced OR4S2 activity, as persistent elevation of intracellular calcium is known to lead to receptor desensitization. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamaldehyde acts on TRPA1 channels (transient receptor potential cation channel subfamily A member 1), affecting intracellular calcium levels. Elevated calcium could attenuate OR4S2 signaling by promoting rapid desensitization or adaptation of olfactory receptors. | ||||||
HC-030031 | 349085-38-7 | sc-203994 sc-203994A | 10 mg 50 mg | $89.00 $333.00 | 2 | |
HC-030031 is an antagonist of TRPA1 channels. By inhibiting TRPA1, this compound can prevent the calcium influx that may indirectly lead to OR4S2 desensitization, thus dampening the receptor's sensitivity to odorants. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red is a nonspecific blocker of many TRP channels. By inhibiting these channels, it could prevent calcium influx that is necessary for the normal function of olfactory receptors like OR4S2, leading to a decrease in their activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a potent inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). By depleting intracellular calcium stores, thapsigargin can disrupt the signaling mechanisms of OR4S2, as these receptors rely on calcium signaling for proper function. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 inhibits receptor-mediated calcium entry channels, which could result in a decrease in intracellular calcium levels that are necessary for OR4S2 receptor activation and subsequent olfactory signal transduction. | ||||||
Mibefradil dihydrochloride | 116666-63-8 | sc-204083 sc-204083A | 10 mg 50 mg | $213.00 $865.00 | 4 | |
Mibefradil is a T-type calcium channel blocker. By inhibiting these channels, mibefradil can lower calcium influx that contributes to the sensitization and responsiveness of olfactory receptors including OR4S2. | ||||||
4-Methyl-2-(1-piperidinyl)-quinoline | 5465-86-1 | sc-483337 | 25 mg | $430.00 | ||
ML204 is an inhibitor of TRPC4/TRPC5 channels (transient receptor potential cation channel subfamily C members 4 and 5). Inhibition of these channels can affect the depolarization events leading to OR4S2 receptor activation, reducing its ability to respond to odorants. | ||||||