Date published: 2025-12-24

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OR4K1 Inhibitors

OR4K1 inhibitors encompass a variety of chemical compounds that target the functional activity of this olfactory receptor through distinct mechanisms. For instance, certain sweeteners and flavor compounds are capable of competitively binding to the receptor sites that OR4K1 typically interacts with, thereby preventing the activation of the receptor by its natural ligands. This competitive inhibition is a direct way to reduce the functional response of OR4K1. Additionally, other compounds can integrate into the cell membrane where OR4K1 is localized, altering the membrane's fluidity and receptor conformation, leading to a decrease in receptor activity. This membrane integration not only affects the structural integrity of the receptor but may also interfere with the receptor's ability to undergo conformational changes necessary for signal transduction. Moreover, specific inhibitors interact with the signaling pathways directly linked to OR4K1's function. Some of these inhibitors desensitize sensory neurons, which are crucial for the propagation of signals initiated by OR4K1 activation, effectively dampening the receptor's signaling. Others can modulate the neuronal response by triggering sensations, such as cooling, that are known to influence the activity of olfactory receptors indirectly. Furthermore, metallic ions introduced into the olfactory system can alter receptor structure or function, thereby reducing OR4K1's response.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Acesulfame Potassium

55589-62-3sc-210736
25 g
$240.00
(0)

This compound interacts with taste receptors that share signaling pathways with OR4K1, potentially altering its activity by competitive binding or downstream signaling interference.

Eugenol

97-53-0sc-203043
sc-203043A
sc-203043B
1 g
100 g
500 g
$31.00
$61.00
$214.00
2
(1)

A phenolic compound that can alter olfactory receptor function by integrating into the cell membrane and changing its fluidity, which may affect OR4K1's receptor activation process.

Zinc

7440-66-6sc-213177
100 g
$47.00
(0)

Zinc ions can modulate olfactory receptor activity, and may inhibit OR4K1 by altering its receptor structure or function.

Capsaicin

404-86-4sc-3577
sc-3577C
sc-3577D
sc-3577A
50 mg
250 mg
500 mg
1 g
$94.00
$173.00
$255.00
$423.00
26
(1)

This vanilloid compound can affect neuron signaling and may inhibit OR4K1 through desensitization of sensory neurons that are involved in receptor signaling.

(±)-Menthol

89-78-1sc-250299
sc-250299A
100 g
250 g
$38.00
$67.00
(0)

As a ligand for cold-sensitive ion channels, menthol's cooling effect might inhibit OR4K1 activity indirectly by modulating the neuronal response in olfactory pathways.

Cinnamic Aldehyde

104-55-2sc-294033
sc-294033A
100 g
500 g
$102.00
$224.00
(0)

This compound can interact with olfactory receptors, potentially inhibiting OR4K1 by modifying the receptor's binding sites or affecting receptor-mediated signaling.

Isopentyl acetate

123-92-2sc-250190
sc-250190A
100 ml
500 ml
$105.00
$221.00
(0)

Commonly known as a banana flavor, it may inhibit OR4K1 by binding to the receptor site, thus preventing the binding of the natural ligand.

Naphthalene

91-20-3sc-215533
sc-215533A
250 mg
5 g
$20.00
$36.00
(0)

This polycyclic aromatic hydrocarbon may inhibit OR4K1 by integrating into the cell membrane, disrupting lipid bilayer integrity, and altering receptor function.

(±)-Citronellal

106-23-0sc-234400
100 ml
$51.00
(0)

Terpenoids like citronellal can inhibit olfactory receptors by binding to receptor sites or affecting the signaling pathways they are involved in.

D-Limonene

5989-27-5sc-205283
sc-205283A
100 ml
500 ml
$82.00
$126.00
3
(1)

A common terpene that may inhibit OR4K1 by binding to its active site or interfering with the receptor's signaling cascade within the olfactory system.