OR4A5 Activators
OR4A5 include a variety of organic compounds that are primarily known as odorants. These molecules are capable of binding to the ligand-binding domain of OR4A5, which is a G protein-coupled receptor (GPCR) involved in olfactory signal transduction. When Acetophenone encounters OR4A5, it fits into the receptor's binding site, triggering a conformational change that activates the G protein signaling cascade, an essential process for the perception of smell. Similarly, Ethyl vanillin and Isoamyl acetate serve as direct agonists to OR4A5 by binding to its ligand-binding domain. This interaction induces activation of the receptor, leading to a cascade of intracellular events that culminate in the activation of olfactory sensory neurons. Methyl salicylate, Benzaldehyde, and Anisole also directly activate OR4A5 through similar mechanisms, with each molecule having a distinct shape that allows it to interact with the receptor's active site, consequently initiating the GPCR pathway and enabling the functional activation of the protein.
Vanillin, Cinnamaldehyde, and Heptanal contribute to the activation of OR4A5 by binding to the receptor and acting as agonists. This binding induces a series of molecular events, including the activation of associated G proteins, which transduce the signal to the interior of the olfactory sensory neuron, ultimately leading to a sensory response. Citral, Eugenol, and Limonene are additional chemical activators of OR4A5 that bind to the receptor and activate the G protein-coupled signaling mechanism. Each of these chemicals has a unique molecular structure that allows them to interact with OR4A5, facilitating the receptor's ability to relay olfactory information through the GPCR signaling pathways specific to the perception of odors. This direct binding and activation of OR4A5 by these odorant molecules are crucial for the functional response of olfactory sensory neurons, which is central to the sense of smell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
Acetophenone is a known odorant that directly activates the olfactory receptor OR4A5 by binding to its ligand-binding site, thereby triggering the G protein-coupled receptor (GPCR) cascade that results in the perception of the odor. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
3-Ethoxy-4-hydroxybenzaldehyde binds specifically to OR4A5 as an agonist, initiating a GPCR-mediated signal transduction pathway that leads to sensory neuron activation, which is a direct functional activation of the protein. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl acetate is another odorant that can interact directly with OR4A5, causing a conformational change that activates the G protein signaling pathway associated with this olfactory receptor. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate activates OR4A5 by fitting into the ligand-binding domain of the receptor, which induces a signal transduction mechanism involving G proteins and leads to the activation of downstream signaling cascades specific to olfactory signaling. | ||||||
Anisole | 100-66-3 | sc-233877 sc-233877A | 500 ml 2.5 L | $65.00 $204.00 | ||
Anisole serves as an agonist to OR4A5, directly interacting with the binding site of the receptor, which triggers the G protein-coupled cascade and results in the functional activation of the olfactory signaling pathway. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin is recognized by OR4A5, where it binds and acts as an agonist, causing activation of the G protein-coupled signaling pathway directly associated with this olfactory receptor protein. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamaldehyde directly activates OR4A5 by binding to its ligand-binding site, initiating a GPCR-mediated signal transduction pathway that leads to the activation of olfactory sensory neurons. | ||||||
Heptaldehyde | 111-71-7 | sc-250089 sc-250089A | 2 ml 100 ml | $30.00 $59.00 | ||
Heptanal interacts with OR4A5 as a direct agonist, binding to the receptor's active site and causing activation of the G protein signaling pathway that this olfactory receptor is part of. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral is known to activate OR4A5 by directly binding to the receptor's ligand pocket, initiating the G protein-coupled activation pathway specific to olfactory GPCRs. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol activates OR4A5 by directly interacting with its ligand-binding domain, triggering the associated G protein cascade and leading to the functional activation of the olfactory signal transduction pathway. | ||||||