OR2Z1 Activators
Chemical activators of olfactory receptor OR2Z1 include a range of compounds typically found in essential oils and flavorings. These activators, such as citral, eugenol, menthol, geraniol, isoamyl acetate, anethole, cinnamaldehyde, isoeugenol, limonene, benzaldehyde, ethyl vanillin, and hexyl acetate, share the ability to bind to and initiate a signaling cascade within the OR2Z1 protein. The process begins when one of these chemicals encounters OR2Z1, fitting into the receptor's ligand-binding domain like a key into a lock. This interaction prompts a structural alteration in the receptor, which in turn triggers the associated G-protein to exchange GDP for GTP, thus becoming activated.
Upon activation, the G-protein then engages with adenylate cyclase, stimulating this enzyme to convert ATP into cyclic AMP (cAMP). As cAMP accumulates, it serves as a secondary messenger, activating protein kinase A (PKA). Activated PKA phosphorylates various target proteins within the cell, leading to a chain reaction that ultimately results in a physiological response. This series of events translates the chemical signal of the activating compound into a biological effect. Each of the aforementioned chemicals can effectively initiate this pathway by binding to OR2Z1, ensuring that the receptor can respond to a diverse array of scent molecules, thereby contributing to the complexity and richness of the olfactory system's capabilities.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a component of lemongrass oil, is known to bind to and activate some olfactory receptors, which may include OR2Z1, leading to the activation of downstream signaling pathways such as the G-protein pathway, resulting in the activation of adenylate cyclase and increased cAMP, which in turn can activate protein kinase A (PKA) and lead to activation of target proteins. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol, a compound found in clove oil, has been demonstrated to activate certain olfactory receptors by binding to the ligand-binding site, which could activate OR2Z1 by triggering the G-protein signaling cascade, thus leading to the activation of various downstream effectors including adenylate cyclase, cAMP production, and PKA activation. | ||||||
(−)-Menthol | 2216-51-5 | sc-202705 sc-202705A | 1 g 50 g | $20.00 $40.00 | 2 | |
Menthol, a compound from peppermint oil, is a known activator of certain olfactory receptors; it can activate OR2Z1 through the G-protein coupled receptor pathway, leading to the activation of adenylate cyclase, thereby increasing cAMP levels and activating PKA, which can phosphorylate and activate downstream targets. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol, present in rose oil and palmarosa oil, activates olfactory receptors and could activate OR2Z1. The activation process involves binding to the receptor, inducing a conformational change, and activating the associated G-protein, which then activates adenylate cyclase, increasing cAMP and activating PKA, culminating in the phosphorylation and activation of target proteins. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isoamyl acetate, commonly known as banana oil, is an ester that can activate certain olfactory receptors. Binding of isoamyl acetate to OR2Z1 likely triggers the G-protein signaling pathway, leading to activation of adenylate cyclase, a rise in cAMP levels, and subsequent activation of PKA, which then can activate various cellular proteins. | ||||||
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $565.00 $310.00 | ||
Anethole, a component of anise and fennel, is known to activate certain olfactory receptors, so it may activate OR2Z1 by binding and activating the G-protein coupled receptor signaling, which would result in the activation of adenylate cyclase, followed by an increase in cAMP and activation of PKA, ultimately leading to the activation of downstream proteins. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Cinnamaldehyde, the active component in cinnamon oil, could activate OR2Z1 by binding to the receptor, which would activate the G-protein coupled receptor pathway, leading to the activation of adenylate cyclase, subsequent cAMP production, and activation of PKA, resulting in the activation of downstream signaling molecules. | ||||||
Isoeugenol | 97-54-1 | sc-250186 sc-250186A | 5 g 100 g | $62.00 $52.00 | ||
Isoeugenol is another compound found in clove oil and can activate certain olfactory receptors. When binding to OR2Z1, it would activate the G-protein, subsequently activate adenylate cyclase, increase cAMP levels, and activate PKA, which would then activate a range of cellular proteins. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $82.00 $126.00 | 3 | |
Limonene, a major component of citrus oil, is known to activate certain olfactory receptors. It might activate OR2Z1 by binding to the receptor, initiating the G-protein signaling cascade, leading to activation of adenylate cyclase, an increase in cAMP, and activation of PKA, resulting in activation of cellular response elements. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
3-Ethoxy-4-hydroxybenzaldehyde, a synthetic form of vanilla flavor, can activate olfactory receptors. Its activation of OR2Z1 would involve binding to the receptor, triggering the G-protein coupled receptor pathway, leading to the activation of adenylate cyclase, an increase in cAMP, and activation of PKA, which would activate target proteins. | ||||||